methyl 4-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)benzoate

Base Information

Chemical Name:methyl 4-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)benzoate
CAS No.:1283092-12-5
Molecular Formula:C₂₈H₃₁N₃O₃Si
Molecular Weight:485.658
Hs Code.:

Synonyms:methyl 4-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)benzoate

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Chemical Property of methyl 4-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)benzoate

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Technology Process of methyl 4-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)benzoate

There total 4 articles about methyl 4-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 405554-89-4
4-(5-bromo-2-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)pyridine

: 99768-12-4
4-methoxycarbonylphenylboronic acid

: 1283092-12-5
methyl 4-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)benzoate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 90 ℃; for 16h; Inert atmosphere;

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1283092-12-5
methyl 4-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; oil / 0.5 h / 0 °C

1.2: 0 - 20 °C

2.1: bromine; sodium carbonate / dichloromethane; water / 0.67 h / 20 °C

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 16 h / 90 °C / Inert atmosphere

With bromine; sodium hydride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; oil;

Reference yield:

: 405554-88-3
4-(2-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)pyridine

: 1283092-12-5
methyl 4-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: bromine; sodium carbonate / dichloromethane; water / 0.67 h / 20 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 16 h / 90 °C / Inert atmosphere

With bromine; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; water;