C₃₈H₃₇BrN₄O₉

Base Information

Chemical Name:C₃₈H₃₇BrN₄O₉
CAS No.:793728-21-9
Molecular Formula:C₃₈H₃₇BrN₄O₉
Molecular Weight:773.637
Hs Code.:

C<sub>38</sub>H<sub>37</sub>BrN<sub>4</sub>O<sub>9</sub>

Synonyms:C₃₈H₃₇BrN₄O₉

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Chemical Property of C₃₈H₃₇BrN₄O₉

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Technology Process of C₃₈H₃₇BrN₄O₉

There total 16 articles about C₃₈H₃₇BrN₄O₉ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 793728-21-9
C₃₈H₃₇BrN₄O₉

Guidance literature:: Multi-step reaction with 15 steps

1.1: 92 percent / EDC*H₂O; HOBt*H₂O; Et₃N / CH₂Cl₂ / 12 h / 25 °C

2.1: 80 percent / Burgess reagent / tetrahydrofuran / 4 h / Heating

3.1: 90 percent / DBU; BrCCl₃ / CH₂Cl₂ / 3 h / 25 °C

4.1: 83 percent / LiBH₄ / ethanol; tetrahydrofuran / 0 - 25 °C

5.1: NaHMDS / tetrahydrofuran / -78 °C

5.2: 72 percent / n-tetrabutylammonium iodide / tetrahydrofuran / 36 h / 25 °C

6.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

6.2: 73 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C

7.1: 47 percent / p-toluenesulfonic acid monohydrate / 1,2-dichloro-ethane / 0.42 h / Heating

8.1: 4.6 g / aq. NaHCO₃ / dioxane / 2 h / 25 °C

9.1: 85 percent / K₂CO₃ / acetone / 0 - 25 °C

10.1: aq. LiOH / tetrahydrofuran; methanol / 0.33 h / Heating

11.1: trifluoroacetic acid / 0.17 h

12.1: 0.220 g / HATU; 2,4,6-collidine / CH₂Cl₂; dimethylformamide / 12 h / 25 °C

13.1: 65 percent / BCl₃ / CH₂Cl₂ / 2 h / -78 °C

14.1: 70 percent / Et₃N; 4-dimethylaminopyridine / dioxane / 1 h / 25 °C

15.1: 1-hydroxy-1,2-benziodoxol-3(1H)-one / dimethylsulfoxide / 2 h / 25 °C

With 2,4,6-trimethyl-pyridine; dmap; lithium hydroxide; lithium borohydride; n-butyllithium; 1-hydroxy-1,2-benzodioxol-3-(1H)-one; Burgess Reagent; Bromotrichloromethane; sodium hexamethyldisilazane; boron trichloride; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ja040092i

Reference yield:

: 158068-97-4
2-<(S)-1--2-methylpropyl>-4-carbomethoxyoxazole

: 793728-21-9
C₃₈H₃₇BrN₄O₉

Guidance literature:: Multi-step reaction with 12 steps

1.1: 83 percent / LiBH₄ / ethanol; tetrahydrofuran / 0 - 25 °C

2.1: NaHMDS / tetrahydrofuran / -78 °C

2.2: 72 percent / n-tetrabutylammonium iodide / tetrahydrofuran / 36 h / 25 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

3.2: 73 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C

4.1: 47 percent / p-toluenesulfonic acid monohydrate / 1,2-dichloro-ethane / 0.42 h / Heating

5.1: 4.6 g / aq. NaHCO₃ / dioxane / 2 h / 25 °C

6.1: 85 percent / K₂CO₃ / acetone / 0 - 25 °C

7.1: aq. LiOH / tetrahydrofuran; methanol / 0.33 h / Heating

8.1: trifluoroacetic acid / 0.17 h

9.1: 0.220 g / HATU; 2,4,6-collidine / CH₂Cl₂; dimethylformamide / 12 h / 25 °C

10.1: 65 percent / BCl₃ / CH₂Cl₂ / 2 h / -78 °C

11.1: 70 percent / Et₃N; 4-dimethylaminopyridine / dioxane / 1 h / 25 °C

12.1: 1-hydroxy-1,2-benziodoxol-3(1H)-one / dimethylsulfoxide / 2 h / 25 °C

With 2,4,6-trimethyl-pyridine; dmap; lithium hydroxide; lithium borohydride; n-butyllithium; 1-hydroxy-1,2-benzodioxol-3-(1H)-one; sodium hexamethyldisilazane; boron trichloride; sodium hydrogencarbonate; potassium carbonate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ja040092i

Reference yield:

: 71017-98-6
methyl (2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-3-hydroxypropanoate

: 793728-21-9
C₃₈H₃₇BrN₄O₉

Guidance literature:: Multi-step reaction with 14 steps

1.1: 80 percent / Burgess reagent / tetrahydrofuran / 4 h / Heating

2.1: 90 percent / DBU; BrCCl₃ / CH₂Cl₂ / 3 h / 25 °C

3.1: 83 percent / LiBH₄ / ethanol; tetrahydrofuran / 0 - 25 °C

4.1: NaHMDS / tetrahydrofuran / -78 °C

4.2: 72 percent / n-tetrabutylammonium iodide / tetrahydrofuran / 36 h / 25 °C

5.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

5.2: 73 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C

6.1: 47 percent / p-toluenesulfonic acid monohydrate / 1,2-dichloro-ethane / 0.42 h / Heating

7.1: 4.6 g / aq. NaHCO₃ / dioxane / 2 h / 25 °C

8.1: 85 percent / K₂CO₃ / acetone / 0 - 25 °C

9.1: aq. LiOH / tetrahydrofuran; methanol / 0.33 h / Heating

10.1: trifluoroacetic acid / 0.17 h

11.1: 0.220 g / HATU; 2,4,6-collidine / CH₂Cl₂; dimethylformamide / 12 h / 25 °C

12.1: 65 percent / BCl₃ / CH₂Cl₂ / 2 h / -78 °C

13.1: 70 percent / Et₃N; 4-dimethylaminopyridine / dioxane / 1 h / 25 °C

14.1: 1-hydroxy-1,2-benziodoxol-3(1H)-one / dimethylsulfoxide / 2 h / 25 °C

With 2,4,6-trimethyl-pyridine; dmap; lithium hydroxide; lithium borohydride; n-butyllithium; 1-hydroxy-1,2-benzodioxol-3-(1H)-one; Burgess Reagent; Bromotrichloromethane; sodium hexamethyldisilazane; boron trichloride; sodium hydrogencarbonate; potassium carbonate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ja040092i