dimethyl 2-(4-fluorophenyl)-5-(1-methylethyl)-1-(3-oxopropyl)-1H-pyrrole-3,4-dicarboxylate

Base Information

Chemical Name:dimethyl 2-(4-fluorophenyl)-5-(1-methylethyl)-1-(3-oxopropyl)-1H-pyrrole-3,4-dicarboxylate
CAS No.:104568-96-9
Molecular Formula:C₂₀H₂₂FNO₅
Molecular Weight:375.397
Hs Code.:

Synonyms:dimethyl 2-(4-fluorophenyl)-5-(1-methylethyl)-1-(3-oxopropyl)-1H-pyrrole-3,4-dicarboxylate

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Chemical Property of dimethyl 2-(4-fluorophenyl)-5-(1-methylethyl)-1-(3-oxopropyl)-1H-pyrrole-3,4-dicarboxylate

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Technology Process of dimethyl 2-(4-fluorophenyl)-5-(1-methylethyl)-1-(3-oxopropyl)-1H-pyrrole-3,4-dicarboxylate

There total 3 articles about dimethyl 2-(4-fluorophenyl)-5-(1-methylethyl)-1-(3-oxopropyl)-1H-pyrrole-3,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 104568-72-1
dimethyl 1-<2-(1,3-dioxolan-2-yl)ethyl>-2-(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrole-3,4-dicarboxylate

: 104568-96-9
dimethyl 2-(4-fluorophenyl)-5-(1-methylethyl)-1-(3-oxopropyl)-1H-pyrrole-3,4-dicarboxylate

Guidance literature:: With water; toluene-4-sulfonic acid; In acetone; for 48h; Heating;
DOI:10.1021/jm00105a056

Reference yield:

: 104568-95-8
N-<2-(1,3-dioxolan-2-yl)ethyl>-DL-valine methyl ester

: 104568-96-9
dimethyl 2-(4-fluorophenyl)-5-(1-methylethyl)-1-(3-oxopropyl)-1H-pyrrole-3,4-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / CH₂Cl₂ / 1.) 0 deg C, 50 min, 2.) RT, 60 min

2: NaOH / methanol; H₂O / 3 h / Heating

3: 89 percent / acetic anhydride / 2 h / Ambient temperature

4: 90 percent / p-TSA, H₂O / acetone / 48 h / Heating

With sodium hydroxide; water; acetic anhydride; toluene-4-sulfonic acid; triethylamine; In methanol; dichloromethane; water; acetone;
DOI:10.1021/jm00105a056

Reference yield:

: 104568-93-6
N-<2-(1,3-dioxolan-2-yl)ethyl>-N-(4-fluorobenzoyl)-DL-valine

: 104568-96-9
dimethyl 2-(4-fluorophenyl)-5-(1-methylethyl)-1-(3-oxopropyl)-1H-pyrrole-3,4-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / acetic anhydride / 2 h / Ambient temperature

2: 90 percent / p-TSA, H₂O / acetone / 48 h / Heating

With water; acetic anhydride; toluene-4-sulfonic acid; In acetone;
DOI:10.1021/jm00105a056