(1R,2S)-ethyl 2-(1-(4’-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxamido)cyclohexanecarboxylate

Base Information

• Chemical Name: (1R,2S)-ethyl 2-(1-(4’-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxamido)cyclohexanecarboxylate
• CAS No.: 1620085-00-8
• Molecular Formula: C₃₄H₄₆N₂O₃
• Molecular Weight: 530.751
• Mol file: 1620085-00-8.mol

Synonyms:(1R,2S)-ethyl 2-(1-(4’-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxamido)cyclohexanecarboxylate

Chemical Property of (1R,2S)-ethyl 2-(1-(4’-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxamido)cyclohexanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S)-ethyl 2-(1-(4’-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxamido)cyclohexanecarboxylate

There total 2 articles about (1R,2S)-ethyl 2-(1-(4’-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxamido)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-1-(4’-(2-(2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxylic acid (1620084-99-2) + (1R,2S)-ethyl 2-aminocyclohexanecarboxylate hydrochloride (180979-18-4,1346773-57-6) → (1R,2S)-ethyl 2-(1-(4’-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxamido)cyclohexanecarboxylate (1620085-00-8)

Guidance literature:

With triethylamine; HATU; In N,N-dimethyl-formamide;

Reference yield:

1-(4-chlorophenyl)cyclopentane-1-carboxylic acid (80789-69-1) → (1R,2S)-ethyl 2-(1-(4’-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxamido)cyclohexanecarboxylate (1620085-00-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; 1,4-dioxane / 0.17 h / 150 °C

2: triethylamine; HATU / N,N-dimethyl-formamide

With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sodium carbonate; triethylamine; HATU; In 1,4-dioxane; water; N,N-dimethyl-formamide;

upstream raw materials:

(R)-1-(4’-(2-(2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxylic acid

(1R,2S)-ethyl 2-aminocyclohexanecarboxylate hydrochloride

1-(4-chlorophenyl)cyclopentane-1-carboxylic acid