(E)-3-[2-(5-Methyl-2-phenyl-oxazol-4-ylmethyl)-benzofuran-5-yl]-acrylic acid

Base Information

Chemical Name:(E)-3-[2-(5-Methyl-2-phenyl-oxazol-4-ylmethyl)-benzofuran-5-yl]-acrylic acid
CAS No.:181931-77-1
Molecular Formula:C₂₂H₁₇NO₄
Molecular Weight:359.381
Hs Code.:

Synonyms:(E)-3-[2-(5-Methyl-2-phenyl-oxazol-4-ylmethyl)-benzofuran-5-yl]-acrylic acid

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Chemical Property of (E)-3-[2-(5-Methyl-2-phenyl-oxazol-4-ylmethyl)-benzofuran-5-yl]-acrylic acid

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Technology Process of (E)-3-[2-(5-Methyl-2-phenyl-oxazol-4-ylmethyl)-benzofuran-5-yl]-acrylic acid

There total 5 articles about (E)-3-[2-(5-Methyl-2-phenyl-oxazol-4-ylmethyl)-benzofuran-5-yl]-acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 141-82-2
malonic acid

: 132646-34-5
2-(5-methyl-2-phenyl-4-oxazolyl)methyl-5-benzofurancarboxaldehyde

: 181931-77-1
(E)-3-[2-(5-Methyl-2-phenyl-oxazol-4-ylmethyl)-benzofuran-5-yl]-acrylic acid

Guidance literature:: With pyridine; In ethanol; for 24h; Heating;
DOI:10.1021/jm960230h

Reference yield:

: 60032-63-5
4-hydroxy-3-iodo-benzaldehyde

: 181931-77-1
(E)-3-[2-(5-Methyl-2-phenyl-oxazol-4-ylmethyl)-benzofuran-5-yl]-acrylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / Cu₂O, (PPh₃)2PdCl₂, pyridine / Heating

2: 82 percent / pyridine / ethanol / 24 h / Heating

With pyridine; copper(I) oxide; bis-triphenylphosphine-palladium(II) chloride; In ethanol;
DOI:10.1021/jm960230h

Reference yield:

: 6813-61-2
2-(benzoylamino)-4-pentynoic acid

: 181931-77-1
(E)-3-[2-(5-Methyl-2-phenyl-oxazol-4-ylmethyl)-benzofuran-5-yl]-acrylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) pyridine, 2.) H₂O / 1.) 90 deg c, 1 h, 2.) from 85 to 90 deg C, 20 min

2: trifluoroacetic acid anhydride / trifluoroacetic acid / 6 h / 35 - 40 °C

3: 65 percent / Cu₂O, (PPh₃)2PdCl₂, pyridine / Heating

4: 82 percent / pyridine / ethanol / 24 h / Heating

With pyridine; copper(I) oxide; bis-triphenylphosphine-palladium(II) chloride; water; trifluoroacetic anhydride; In ethanol; trifluoroacetic acid;
DOI:10.1021/jm960230h