pivaloyloxymethyl (1R,5S,6S)-2-[(1-(4-fluorobenzyl)azetidin-3-yl)thio]-6-[(R)-1-hydroxyethyl]-1-methyl-carbapen-2-em-3-carboxylate

Base Information

Chemical Name:pivaloyloxymethyl (1R,5S,6S)-2-[(1-(4-fluorobenzyl)azetidin-3-yl)thio]-6-[(R)-1-hydroxyethyl]-1-methyl-carbapen-2-em-3-carboxylate
CAS No.:1158510-08-7
Molecular Formula:C₂₆H₃₃FN₂O₆S
Molecular Weight:520.622
Hs Code.:

Synonyms:pivaloyloxymethyl (1R,5S,6S)-2-[(1-(4-fluorobenzyl)azetidin-3-yl)thio]-6-[(R)-1-hydroxyethyl]-1-methyl-carbapen-2-em-3-carboxylate

Suppliers and Price of pivaloyloxymethyl (1R,5S,6S)-2-[(1-(4-fluorobenzyl)azetidin-3-yl)thio]-6-[(R)-1-hydroxyethyl]-1-methyl-carbapen-2-em-3-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of pivaloyloxymethyl (1R,5S,6S)-2-[(1-(4-fluorobenzyl)azetidin-3-yl)thio]-6-[(R)-1-hydroxyethyl]-1-methyl-carbapen-2-em-3-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of pivaloyloxymethyl (1R,5S,6S)-2-[(1-(4-fluorobenzyl)azetidin-3-yl)thio]-6-[(R)-1-hydroxyethyl]-1-methyl-carbapen-2-em-3-carboxylate

There total 2 articles about pivaloyloxymethyl (1R,5S,6S)-2-[(1-(4-fluorobenzyl)azetidin-3-yl)thio]-6-[(R)-1-hydroxyethyl]-1-methyl-carbapen-2-em-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 18997-19-8
Chloromethyl pivalate

: 878534-37-3
(1R,5S,6S)-2-[(1-(4-fluorobenzyl)azetidin-3-yl)thio]-6-[(R)-1-hydroxyethyl]-1-methyl-carbapen-2-em-3-carboxylic acid

: 1158510-08-7
pivaloyloxymethyl (1R,5S,6S)-2-[(1-(4-fluorobenzyl)azetidin-3-yl)thio]-6-[(R)-1-hydroxyethyl]-1-methyl-carbapen-2-em-3-carboxylate

Guidance literature:: With N-benzyl-N,N,N-triethylammonium chloride; triethylamine; In N,N-dimethyl-formamide; at 65 - 70 ℃; for 2h; Product distribution / selectivity;

Reference yield: 72.0%

: 878534-37-3
(1R,5S,6S)-2-[(1-(4-fluorobenzyl)azetidin-3-yl)thio]-6-[(R)-1-hydroxyethyl]-1-methyl-carbapen-2-em-3-carboxylic acid

: 53064-79-2
iodomethyl pivaloate

: 1158510-08-7
pivaloyloxymethyl (1R,5S,6S)-2-[(1-(4-fluorobenzyl)azetidin-3-yl)thio]-6-[(R)-1-hydroxyethyl]-1-methyl-carbapen-2-em-3-carboxylate

Guidance literature:: With potassium carbonate; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h; Product distribution / selectivity;