tert-butyl 3-(1H-indol-3-yl)-2-oxo-3-(2-oxo-2-phenylethyl)indoline-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-(1H-indol-3-yl)-2-oxo-3-(2-oxo-2-phenylethyl)indoline-1-carboxylate
CAS No.:1360873-06-8
Molecular Formula:C₂₉H₂₆N₂O₄
Molecular Weight:466.536
Hs Code.:

Synonyms:tert-butyl 3-(1H-indol-3-yl)-2-oxo-3-(2-oxo-2-phenylethyl)indoline-1-carboxylate

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Chemical Property of tert-butyl 3-(1H-indol-3-yl)-2-oxo-3-(2-oxo-2-phenylethyl)indoline-1-carboxylate

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Technology Process of tert-butyl 3-(1H-indol-3-yl)-2-oxo-3-(2-oxo-2-phenylethyl)indoline-1-carboxylate

There total 2 articles about tert-butyl 3-(1H-indol-3-yl)-2-oxo-3-(2-oxo-2-phenylethyl)indoline-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1360873-00-2
C₂₁H₂₀N₂O₄

: 72328-04-2
methyl 1-phenylvinylcarbamate

: 1360873-06-8
tert-butyl 3-(1H-indol-3-yl)-2-oxo-3-(2-oxo-2-phenylethyl)indoline-1-carboxylate

Guidance literature:: C₂₁H₂₀N₂O₄; methyl 1-phenylvinylcarbamate; With (S)-[3,3'-di(2-naphthyl)-1,1'-binaphthyl-2,2'-diyl]phosphoric acid; In dichloromethane; at 20 ℃;

optical yield given as %ee; enantioselective reaction; Acidic conditions;
DOI:10.1002/anie.201107079

Reference yield:

: 614-20-0
3-oxo-3-phenylpropionic acid

: 1360873-00-2
C₂₁H₂₀N₂O₄

: 1360873-06-8
tert-butyl 3-(1H-indol-3-yl)-2-oxo-3-(2-oxo-2-phenylethyl)indoline-1-carboxylate

: tert-butyl (R)-3-(1H-indol-3-yl)-2-oxo-3-(2-oxo-2-phenylethyl)indoline-1-carboxylate

Guidance literature:: With C₄₈H₂₅F₁₂O₄P; sodium sulfate; In dichloromethane; at -35 ℃; for 36h; Overall yield = 86 %; Overall yield = 40.2 mg; enantioselective reaction;
DOI:10.1021/acs.orglett.5b00159