methyl (2R,3S)-3-benzylamino-2-(dimethylphenylsilyl)-3-phenylpropionate

Base Information

Chemical Name:methyl (2R*,3S*)-3-benzylamino-2-(dimethylphenylsilyl)-3-phenylpropionate
CAS No.:146060-96-0
Molecular Formula:C₂₅H₂₉NO₂Si
Molecular Weight:403.596
Hs Code.:

Synonyms:methyl (2R*,3S*)-3-benzylamino-2-(dimethylphenylsilyl)-3-phenylpropionate

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Chemical Property of methyl (2R*,3S*)-3-benzylamino-2-(dimethylphenylsilyl)-3-phenylpropionate

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Technology Process of methyl (2R*,3S*)-3-benzylamino-2-(dimethylphenylsilyl)-3-phenylpropionate

There total 1 articles about methyl (2R*,3S*)-3-benzylamino-2-(dimethylphenylsilyl)-3-phenylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42414-77-7
(dimethylphenylsilyl)ketene

: 1067-52-3
tributyltin methoxide

: 780-25-6
N-benzylidene benzylamine

: 146060-96-0
methyl (2R*,3S*)-3-benzylamino-2-(dimethylphenylsilyl)-3-phenylpropionate

Guidance literature:: With titanium tetrachloride; Yield given. Multistep reaction; 1.) CH₂Cl₂, -40 deg C, 2 h 2.) -78 deg C, 1 h, then room temp., overnight;
DOI:10.1039/P19920002813

Reference yield: 89.0%

: 146060-96-0
methyl (2R*,3S*)-3-benzylamino-2-(dimethylphenylsilyl)-3-phenylpropionate

: 146060-97-1
(2R*,3S*)-3-benzylamino-2-(dimethylphenylsilyl)-3-phenylpropan-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; 0 deg C, 10 min, then room temp., 30 min;
DOI:10.1039/P19920002813

Reference yield:

: 146060-96-0
methyl (2R*,3S*)-3-benzylamino-2-(dimethylphenylsilyl)-3-phenylpropionate

: Acetic acid (2R,3S)-3-(acetyl-benzyl-amino)-2-hydroxy-3-phenyl-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / LiAlH₄ / diethyl ether / 0 deg C, 10 min, then room temp., 30 min

2: 95 percent / pyridine / CH₂Cl₂ / 2 h / 0 °C

3: 1.) bromine 2.) Et₃N / 1.) CH₂Cl₂, room temp., 2 h 2.) THF, room temp., 1 h

4: 30percent H₂O₂, KF, KHCO₃ / tetrahydrofuran; methanol

With pyridine; potassium fluoride; lithium aluminium tetrahydride; dihydrogen peroxide; bromine; potassium hydrogencarbonate; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1039/P19920002813