3-{[3-(4-carbamimidoylphenyl)-1-methyl-2,4-dioxo-1,3,8-triazaspiro[4.5]decane-8-carbonyl]amino}-3-phenylpropionic acid ethyl ester

Base Information

Chemical Name:3-{[3-(4-carbamimidoylphenyl)-1-methyl-2,4-dioxo-1,3,8-triazaspiro[4.5]decane-8-carbonyl]amino}-3-phenylpropionic acid ethyl ester
CAS No.:685545-49-7
Molecular Formula:C₂₇H₃₂N₆O₅
Molecular Weight:520.588
Hs Code.:

Synonyms:3-{[3-(4-carbamimidoylphenyl)-1-methyl-2,4-dioxo-1,3,8-triazaspiro[4.5]decane-8-carbonyl]amino}-3-phenylpropionic acid ethyl ester

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Chemical Property of 3-{[3-(4-carbamimidoylphenyl)-1-methyl-2,4-dioxo-1,3,8-triazaspiro[4.5]decane-8-carbonyl]amino}-3-phenylpropionic acid ethyl ester

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Technology Process of 3-{[3-(4-carbamimidoylphenyl)-1-methyl-2,4-dioxo-1,3,8-triazaspiro[4.5]decane-8-carbonyl]amino}-3-phenylpropionic acid ethyl ester

There total 9 articles about 3-{[3-(4-carbamimidoylphenyl)-1-methyl-2,4-dioxo-1,3,8-triazaspiro[4.5]decane-8-carbonyl]amino}-3-phenylpropionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 685545-49-7
3-{[3-(4-carbamimidoylphenyl)-1-methyl-2,4-dioxo-1,3,8-triazaspiro[4.5]decane-8-carbonyl]amino}-3-phenylpropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 94 percent / methanol; H₂O / 20 °C

2: 92 percent / Et₃N / CH₂Cl₂ / 20 °C

3: 89 percent / aq. HCl / 16 h / Heating

4: 86 percent / acetonitrile; CHCl₃ / 6 h / 20 °C

5: 79 percent / aq. NH₄OAc; Cd-Pb couple / tetrahydrofuran / 20 °C / pH 5

6: 79 percent / DIEA / CH₂Cl₂ / 20 °C

7: H₂S (gas); Et₃N; pyridine / 20 °C

8: acetone / 20 °C

9: NH₄OAc / methanol / 20 °C

With pyridine; hydrogenchloride; 10% Cd/Pd; hydrogen sulfide; ammonium acetate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; acetone; acetonitrile; 1: Strecker reaction;
DOI:10.1021/jm030354b

Reference yield:

: 6335-76-8
3-amino-3-phenylpropionic acid ethyl ester

: 685545-49-7
3-{[3-(4-carbamimidoylphenyl)-1-methyl-2,4-dioxo-1,3,8-triazaspiro[4.5]decane-8-carbonyl]amino}-3-phenylpropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / DIEA / CH₂Cl₂ / 9 h / 20 °C

2: 79 percent / DIEA / CH₂Cl₂ / 20 °C

3: H₂S (gas); Et₃N; pyridine / 20 °C

4: acetone / 20 °C

5: NH₄OAc / methanol / 20 °C

With pyridine; hydrogen sulfide; ammonium acetate; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; acetone;
DOI:10.1021/jm030354b

Reference yield:

: 953-79-7
1-benzyl-4-methylaminopiperidine-4-carbonitrile

: 685545-49-7
3-{[3-(4-carbamimidoylphenyl)-1-methyl-2,4-dioxo-1,3,8-triazaspiro[4.5]decane-8-carbonyl]amino}-3-phenylpropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 92 percent / Et₃N / CH₂Cl₂ / 20 °C

2: 89 percent / aq. HCl / 16 h / Heating

3: 86 percent / acetonitrile; CHCl₃ / 6 h / 20 °C

4: 79 percent / aq. NH₄OAc; Cd-Pb couple / tetrahydrofuran / 20 °C / pH 5

5: 79 percent / DIEA / CH₂Cl₂ / 20 °C

6: H₂S (gas); Et₃N; pyridine / 20 °C

7: acetone / 20 °C

8: NH₄OAc / methanol / 20 °C

With pyridine; hydrogenchloride; 10% Cd/Pd; hydrogen sulfide; ammonium acetate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; chloroform; acetone; acetonitrile;
DOI:10.1021/jm030354b