[4-(tert-butoxycarbonylamino-methyl)-benzyl]-carbamic acid benzyl ester

Base Information

• Chemical Name: [4-(tert-butoxycarbonylamino-methyl)-benzyl]-carbamic acid benzyl ester
• CAS No.: 1417694-16-6
• Molecular Formula: C₂₁H₂₆N₂O₄
• Molecular Weight: 370.448

Synonyms:[4-(tert-butoxycarbonylamino-methyl)-benzyl]-carbamic acid benzyl ester

Chemical Property of [4-(tert-butoxycarbonylamino-methyl)-benzyl]-carbamic acid benzyl ester

Chemical Property:

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Technology Process of [4-(tert-butoxycarbonylamino-methyl)-benzyl]-carbamic acid benzyl ester

There total 1 articles about [4-(tert-butoxycarbonylamino-methyl)-benzyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-(Benzyloxycarbonyloxy)succinimide (13139-17-8) + tert-butyl 4-(aminomethyl)benzylcarbamate (108468-00-4) → [4-(tert-butoxycarbonylamino-methyl)-benzyl]-carbamic acid benzyl ester (1417694-16-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 18h;

Reference yield: 99.0%

[4-(tert-butoxycarbonylamino-methyl)-benzyl]-carbamic acid benzyl ester (1417694-16-6) → (4-aminomethyl-benzyl)-carbamic acid benzyl ester hydrochloride (1417694-17-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

Reference yield:

[4-(tert-butoxycarbonylamino-methyl)-benzyl]-carbamic acid benzyl ester (1417694-16-6) → C16H18N2O2*H(1+)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201903045

upstream raw materials:

N-(Benzyloxycarbonyloxy)succinimide

tert-butyl 4-(aminomethyl)benzylcarbamate

Downstream raw materials:

(4-aminomethyl-benzyl)-carbamic acid benzyl ester hydrochloride

{(S)-1-[4-(benzyloxycarbonylamino-methyl)-benzylcarbamoyl]-2-pyridin-3-yl-ethyl}-carbamic acid tert-butyl ester

[(R)-1-{(S)-1-[4-(benzyloxycarbonylamino-methyl)-benzylcarbamoyl]-2-pyridin-3-yl-ethylcarbamoyl}-2-(4-ethoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester

[4-({(S)-2-[(R)-3-(4-ethoxy-phenyl)-2-(4-methyl-benzoylamino)-propionylamino]-3-pyridin-3-yl-propionylamino}-methyl)-benzyl]-carbamic acid benzyl ester

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