(2S,3S)-3-Dibenzylamino-2-phenyl-piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: (2S,3S)-3-Dibenzylamino-2-phenyl-piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 239437-22-0
• Molecular Formula: C₃₀H₃₆N₂O₂
• Molecular Weight: 456.628
• Mol file: 239437-22-0.mol

Synonyms:(2S,3S)-3-Dibenzylamino-2-phenyl-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of (2S,3S)-3-Dibenzylamino-2-phenyl-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3S)-3-Dibenzylamino-2-phenyl-piperidine-1-carboxylic acid tert-butyl ester

There total 3 articles about (2S,3S)-3-Dibenzylamino-2-phenyl-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

Methanesulfonic acid (4S,5S)-5-tert-butoxycarbonylamino-4-dibenzylamino-5-phenyl-pentyl ester (239437-21-9) → (2S,3S)-3-Dibenzylamino-2-phenyl-piperidine-1-carboxylic acid tert-butyl ester (239437-22-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran;

DOI:10.1016/S0040-4039(99)00983-1

Reference yield:

((1S,2S)-2-Dibenzylamino-5-hydroxy-1-phenyl-pentyl)-carbamic acid tert-butyl ester (239437-20-8) → (2S,3S)-3-Dibenzylamino-2-phenyl-piperidine-1-carboxylic acid tert-butyl ester (239437-22-0)

Guidance literature:

Multi-step reaction with 2 steps

1: TEA / CH₂Cl₂

2: 70 percent / NaH / tetrahydrofuran

With TEA; sodium hydride; In tetrahydrofuran; dichloromethane; 1: Esterification / 2: Cyclization;

DOI:10.1016/S0040-4039(99)00983-1

Reference yield:

(4S,5S)-5-tert-Butoxycarbonylamino-4-dibenzylamino-5-phenyl-pentanoic acid ethyl ester → (2S,3S)-3-Dibenzylamino-2-phenyl-piperidine-1-carboxylic acid tert-butyl ester (239437-22-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / LiCl; NaBH₄ / ethanol; tetrahydrofuran

2: TEA / CH₂Cl₂

3: 70 percent / NaH / tetrahydrofuran

With sodium tetrahydroborate; TEA; sodium hydride; lithium chloride; In tetrahydrofuran; ethanol; dichloromethane; 1: Reduction / 2: Esterification / 3: Cyclization;

DOI:10.1016/S0040-4039(99)00983-1

upstream raw materials:

Methanesulfonic acid (4S,5S)-5-tert-butoxycarbonylamino-4-dibenzylamino-5-phenyl-pentyl ester

((1S,2S)-2-Dibenzylamino-5-hydroxy-1-phenyl-pentyl)-carbamic acid tert-butyl ester

Downstream raw materials:

(+)(2S,3S)-3-(2-methoxylbenzylamino)-2-phenylpiperidine hydrochloride

tert-butyl (2S,3S)-3-({[2-(methyloxy)phenyl]methyl}amino)-2-phenylpiperidinecarboxylate

(2S,3S)-3-Amino-1-tert-butoxycarbonyl-2-phenylpiperidine