N-(gamma-phthalylglutamyl)-N'-<7-bromo-5-(2-chlorophenyl)-1,2-dihydro-3H-1,4-benzodiazepine-2-on-1-ylacetyl>piperazine

Base Information

Chemical Name:N-(gamma-phthalylglutamyl)-N'-<7-bromo-5-(2-chlorophenyl)-1,2-dihydro-3H-1,4-benzodiazepine-2-on-1-ylacetyl>piperazine
CAS No.:126494-57-3
Molecular Formula:C₃₄H₂₉BrClN₅O₇
Molecular Weight:734.991
Hs Code.:

Synonyms:N-(gamma-phthalylglutamyl)-N'-<7-bromo-5-(2-chlorophenyl)-1,2-dihydro-3H-1,4-benzodiazepine-2-on-1-ylacetyl>piperazine

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Chemical Property of N-(gamma-phthalylglutamyl)-N'-<7-bromo-5-(2-chlorophenyl)-1,2-dihydro-3H-1,4-benzodiazepine-2-on-1-ylacetyl>piperazine

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Technology Process of N-(gamma-phthalylglutamyl)-N'-<7-bromo-5-(2-chlorophenyl)-1,2-dihydro-3H-1,4-benzodiazepine-2-on-1-ylacetyl>piperazine

There total 1 articles about N-(gamma-phthalylglutamyl)-N'-<7-bromo-5-(2-chlorophenyl)-1,2-dihydro-3H-1,4-benzodiazepine-2-on-1-ylacetyl>piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 126494-62-0
N-<7-bromo-5-(2-chlorophenyl)-1,2-dihydro-3H-1,4-benzodiazepin-2-on-1-ylacetyl>piperazine

: 25830-77-7,3085-92-5
N-phthaloyl-L-glutamic anhydride

: 126494-57-3
N-(gamma-phthalylglutamyl)-N'-<7-bromo-5-(2-chlorophenyl)-1,2-dihydro-3H-1,4-benzodiazepine-2-on-1-ylacetyl>piperazine

Guidance literature:: In 1,4-dioxane; at 60 ℃; for 2h;
DOI:10.1007/BF00764656

Reference yield:

: 126494-57-3
N-(gamma-phthalylglutamyl)-N'-<7-bromo-5-(2-chlorophenyl)-1,2-dihydro-3H-1,4-benzodiazepine-2-on-1-ylacetyl>piperazine

: 126516-07-2
pyroglutamyl-piperazinyl>>glutamine

Guidance literature:: Multi-step reaction with 2 steps

1: 65.8 percent / Na₂CO₃, hydrazine hydrate / H₂O / 72 h / Ambient temperature

2: 78 percent / 2 N NaOH, N-hydroxysussinimide, dicyclohexylcarbodiimide, 15-crown-5-ether / dimethylformamide / 24 h

With sodium hydroxide; 1-hydroxy-pyrrolidine-2,5-dione; 15-crown-5; sodium carbonate; hydrazine hydrate; dicyclohexyl-carbodiimide; In water; N,N-dimethyl-formamide;
DOI:10.1007/BF00764656

Reference yield:

: 126494-57-3
N-(gamma-phthalylglutamyl)-N'-<7-bromo-5-(2-chlorophenyl)-1,2-dihydro-3H-1,4-benzodiazepine-2-on-1-ylacetyl>piperazine

: 126494-65-3
pyroglutamyl-piperazinyl>>glutamylprolinamide

Guidance literature:: Multi-step reaction with 3 steps

1: 65.8 percent / Na₂CO₃, hydrazine hydrate / H₂O / 72 h / Ambient temperature

2: 78 percent / 2 N NaOH, N-hydroxysussinimide, dicyclohexylcarbodiimide, 15-crown-5-ether / dimethylformamide / 24 h

3: 58 percent / N-hydroxysuccinimide, dicyclohexylcarbodiimide / dimethylformamide / 20 h

With sodium hydroxide; 1-hydroxy-pyrrolidine-2,5-dione; 15-crown-5; sodium carbonate; hydrazine hydrate; dicyclohexyl-carbodiimide; In water; N,N-dimethyl-formamide;
DOI:10.1007/BF00764656