N-(5-Bromo-1,3-thiazol-2-YL)-2,2-dimethylpropanamide

Base Information

• Chemical Name: N-(5-Bromo-1,3-thiazol-2-YL)-2,2-dimethylpropanamide
• CAS No.: 840493-84-7
• Molecular Formula: C8H11 Br N2 O S
• Molecular Weight: 263.15
• European Community (EC) Number: 878-994-8
• Nikkaji Number: J2.144.819B
• Mol file: 840493-84-7.mol

Synonyms:840493-84-7;N-(5-BROMO-1,3-THIAZOL-2-YL)-2,2-DIMETHYLPROPANAMIDE;N-(5-Bromothiazol-2-yl)pivalamide;C8H11BrN2OS;SCHEMBL9974179;N-(5-Bromothiazole-2-yl)pivalamide;MFCD12148406;AKOS008998919;AM805403;AS-54841;EN300-110122;W10463;Z86558909

Chemical Property of N-(5-Bromo-1,3-thiazol-2-YL)-2,2-dimethylpropanamide

Chemical Property:

• PSA: 70.23000
• LogP: 2.96320
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 261.97755
• Heavy Atom Count: 13
• Complexity: 205

Purity/Quality:

99% ^*data from raw suppliers

N-(5-Bromothiazol-2-yl)pivalamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)C(=O)NC1=NC=C(S1)Br

Technology Process of N-(5-Bromo-1,3-thiazol-2-YL)-2,2-dimethylpropanamide

There total 1 articles about N-(5-Bromo-1,3-thiazol-2-YL)-2,2-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2,2-dimethyl-N-(thiazol-2-yl)-propionamide (69212-62-0) → N-(5-bromothiazol-2-yl)-2,2-dimethylpropanamide (840493-84-7)

Guidance literature:

With bromine; triethylamine; In chloroform; at 20 ℃; for 3h;

DOI:10.1021/jo0484326

Reference yield: 92.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + N-(5-bromothiazol-2-yl)-2,2-dimethylpropanamide (840493-84-7) → N-(4-bromo-5-formylthiazol-2-yl)-2,2-dimethylpropanamide (840493-87-0)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/jo0484326

Reference yield: 73.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + N-(5-bromothiazol-2-yl)-2,2-dimethylpropanamide (840493-84-7) → N-(4-bromo-5-(1-hydroxycyclohex-1-yl)thiazol-2-yl)-2,2-dimethylpropanamide

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/jo0484326

upstream raw materials:

2,2-dimethyl-N-(thiazol-2-yl)-propionamide

Downstream raw materials:

N-(4-bromo-5-formylthiazol-2-yl)-2,2-dimethylpropanamide

2,2-dimethyl-N-(thiazol-2-yl)-propionamide

Refernces