Technology Process of L-PROLINE, 4-(6-METHOXY-2-PYRIDINYL)-, METHYL ESTER, (4S)-
There total 6 articles about L-PROLINE, 4-(6-METHOXY-2-PYRIDINYL)-, METHYL ESTER, (4S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 2h;
DOI:10.1021/jo048365f
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 99 percent / Et3N / CH2Cl2 / 4 h / 0 °C
2: 91 percent / (COCl)2; Et3N; DMSO / CH2Cl2 / -40 - 20 °C
3: 89 percent / lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 - -20 °C
4: 88 percent / Pd(PPh3)4; LiCl; CuI / tetrahydrofuran / 4 h / 65 °C
5: 100 percent / H2 / Pd/C / methanol / 2 h / 20 °C / atmospheric pressure
6: 100 percent / TFA / CH2Cl2 / 2 h / 20 °C
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; lithium chloride; lithium hexamethyldisilazane;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane;
2: Swern oxidation;
DOI:10.1021/jo048365f
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 91 percent / (COCl)2; Et3N; DMSO / CH2Cl2 / -40 - 20 °C
2: 89 percent / lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 - -20 °C
3: 88 percent / Pd(PPh3)4; LiCl; CuI / tetrahydrofuran / 4 h / 65 °C
4: 100 percent / H2 / Pd/C / methanol / 2 h / 20 °C / atmospheric pressure
5: 100 percent / TFA / CH2Cl2 / 2 h / 20 °C
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; lithium chloride; lithium hexamethyldisilazane;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane;
1: Swern oxidation;
DOI:10.1021/jo048365f
