Spiro[[1]benzothieno[2,3-d]pyrimidine-7(4H),2'-[1,3]dioxolan]-4-one, 1,5,6,8-tetrahydro-

Base Information

• Chemical Name: Spiro[[1]benzothieno[2,3-d]pyrimidine-7(4H),2'-[1,3]dioxolan]-4-one, 1,5,6,8-tetrahydro-
• CAS No.: 835632-37-6
• Molecular Formula: C12H12 N2 O3 S
• Molecular Weight: 264.305
• Mol file: 835632-37-6.mol

Synonyms:Spiro[[1]benzothieno[2,3-d]pyrimidine-7(4H),2’-[1,3]dioxolan]-4-one, 1,5,6,8-tetrahydro-

Chemical Property of Spiro[[1]benzothieno[2,3-d]pyrimidine-7(4H),2'-[1,3]dioxolan]-4-one, 1,5,6,8-tetrahydro-

Chemical Property:

• PSA: 92.45000
• LogP: 1.21640

Purity/Quality:

98% ^*data from raw suppliers

SPIRO[[1]BENZOTHIENO[2,3-D]PYRIMIDINE-7(4H),2'-[1,3]DIOXOLAN]-4-ONE, 1,5,6,8-TETRAHYDRO- 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Spiro[[1]benzothieno[2,3-d]pyrimidine-7(4H),2'-[1,3]dioxolan]-4-one, 1,5,6,8-tetrahydro-

There total 4 articles about Spiro[[1]benzothieno[2,3-d]pyrimidine-7(4H),2'-[1,3]dioxolan]-4-one, 1,5,6,8-tetrahydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

formamide (77287-34-4,77287-35-5,60100-09-6) + 2-amino-6-(2'-spiro[1',3']dioxolane)-6,7-dihydro-4H-benzo[b]thiophen-3-carboxylic acid ethyl ester (173032-58-1) → 5,6-dihydro-3H-spiro[benzo[4,5]thieno[2,3-d]pyrimidine-7,2’-[1,3]dioxolan]-4(8H)-one (835632-37-6)

Guidance literature:

With ammonium formate; at 140 ℃; for 16h;

Reference yield: 88.0%

ammonium formate (16712-16-6,64165-14-6,65387-22-6,70179-79-2,540-69-2) + 2-amino-6-(2'-spiro[1',3']dioxolane)-6,7-dihydro-4H-benzo[b]thiophen-3-carboxylic acid ethyl ester (173032-58-1) → 5,6-dihydro-3H-spiro[benzo[4,5]thieno[2,3-d]pyrimidine-7,2’-[1,3]dioxolan]-4(8H)-one (835632-37-6)

Guidance literature:

In formamide; at 140 ℃; for 16h;

Reference yield: 42.0%

methyl-2-amino-5,7-dihydro-4H-spiro[benzo[b]thiophene-6,2’-[1,3]dioxolane]-3-carboxylate + formamide (77287-34-4,77287-35-5,60100-09-6) → 5,6-dihydro-3H-spiro[benzo[4,5]thieno[2,3-d]pyrimidine-7,2’-[1,3]dioxolan]-4(8H)-one (835632-37-6)

Guidance literature:

With ammonium formate; at 150 ℃; for 0.5h; Microwave irradiation;

DOI:10.1002/cmdc.201402431

upstream raw materials:

ammonium formate

2-amino-6-(2'-spiro[1',3']dioxolane)-6,7-dihydro-4H-benzo[b]thiophen-3-carboxylic acid ethyl ester

formamide

cyclohexanedione monoethylene ketal

Downstream raw materials:

4-{N-(3-chloro-4-(3-fluoro-benzyloxy)phenylamino)}-5,8-dihydro-6H-benzo[4,5]thieno[2,3-d]pyrimidin-7-one

4-(3-chloro-4-fluoro-phenylamino)-5,8-dihydro-6H-benzo[4,5]thieno[2,3-d]pyrimidin-7-one

N-(3-chloro-4-fluorophenyl)-5,8-dihydro-6H-spiro[1-benzothieno[2,3-d]pyrimidine-7,2'-[1,3]dioxolan]-4-amine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 835632-37-6 Spiro[[1]benzothieno[2,3-d]pyrimidine-7(4H),2'-[1,3]dioxolan]-4-one, 1,5,6,8-tetrahydro-

Send

Send

Metric Ton KG G Pound L ML

Send

Send