9-(2,3,5-tri-O-acetyl-1-β-D-ribofuranosyl)-6-chloro-2-<2-(1-hydroxycyclohexyl)-1-ethyn-1-yl>purine

Base Information

Chemical Name:9-(2,3,5-tri-O-acetyl-1-β-D-ribofuranosyl)-6-chloro-2-<2-(1-hydroxycyclohexyl)-1-ethyn-1-yl>purine
CAS No.:141345-32-6
Molecular Formula:C₂₄H₂₇ClN₄O₈
Molecular Weight:534.953
Hs Code.:

Synonyms:9-(2,3,5-tri-O-acetyl-1-β-D-ribofuranosyl)-6-chloro-2-<2-(1-hydroxycyclohexyl)-1-ethyn-1-yl>purine

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Chemical Property of 9-(2,3,5-tri-O-acetyl-1-β-D-ribofuranosyl)-6-chloro-2-<2-(1-hydroxycyclohexyl)-1-ethyn-1-yl>purine

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Technology Process of 9-(2,3,5-tri-O-acetyl-1-β-D-ribofuranosyl)-6-chloro-2-<2-(1-hydroxycyclohexyl)-1-ethyn-1-yl>purine

There total 1 articles about 9-(2,3,5-tri-O-acetyl-1-β-D-ribofuranosyl)-6-chloro-2-<2-(1-hydroxycyclohexyl)-1-ethyn-1-yl>purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 78-27-3
1-Ethynylcyclohexan-1-ol

: 5987-76-8
6-chloro-2-iodo-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine

: 141345-32-6
9-(2,3,5-tri-O-acetyl-1-β-D-ribofuranosyl)-6-chloro-2-<2-(1-hydroxycyclohexyl)-1-ethyn-1-yl>purine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In 1,4-dioxane; for 1h; Ambient temperature;
DOI:10.1021/jm00090a017

Reference yield: 85.0%

: 141345-32-6
9-(2,3,5-tri-O-acetyl-1-β-D-ribofuranosyl)-6-chloro-2-<2-(1-hydroxycyclohexyl)-1-ethyn-1-yl>purine

: 141345-18-8
2-<2-(1-hydroxycyclohexyl)-1-ethyn-1-yl>adenosine

Guidance literature:: With ammonium hydroxide; In 1,4-dioxane; at 70 ℃; for 20h;
DOI:10.1021/jm00090a017

Reference yield:

: 141345-32-6
9-(2,3,5-tri-O-acetyl-1-β-D-ribofuranosyl)-6-chloro-2-<2-(1-hydroxycyclohexyl)-1-ethyn-1-yl>purine

: 1379508-89-0
8-(2-furyl)-2-[2-(1-hydroxycyclohexyl)-1-ethyn-1-yl]-N⁹-propargyladenine

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium hydroxide / 1,4-dioxane; water / 22 h / 70 °C / Sealed tube

2.1: hydrogenchloride / 1,4-dioxane; water / 5.5 h / 100 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 3 h

4.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1.5 h

4.2: 4.5 h

5.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.42 h / 100 °C

With hydrogenchloride; ammonium hydroxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide;