pyrrolo[3,2-f]indole-2,3,5,6(1H,7H)-tetrone

Base Information

• Chemical Name: pyrrolo[3,2-f]indole-2,3,5,6(1H,7H)-tetrone
• CAS No.: 16898-43-4
• Molecular Formula: C₁₀H₄N₂O₄
• Molecular Weight: 216.153
• Mol file: 16898-43-4.mol

Synonyms:2H,3H,5H,6H‐benzo[1,2‐b:5,4‐b′]dipyrrole‐2,3,5,6‐tetraone

Chemical Property of pyrrolo[3,2-f]indole-2,3,5,6(1H,7H)-tetrone

Chemical Property:

• Melting Point: 214-215 °C(Solv: ethyl acetate (141-78-6))
• PKA: 8.97±0.20(Predicted)
• Density: 1.719±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of pyrrolo[3,2-f]indole-2,3,5,6(1H,7H)-tetrone

There total 4 articles about pyrrolo[3,2-f]indole-2,3,5,6(1H,7H)-tetrone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N,N′‐(1,3‐phenylene)bis(2‐(hydroxyimino)acetamide) → 2H,3H,5H,6H‐benzo[1,2‐b:5,4‐b′]dipyrrole‐2,3,5,6‐tetraone (16898-43-4)

Guidance literature:

With sulfuric acid; at 80 ℃; for 0.333333h;

DOI:10.1002/bio.3446

Reference yield:

m‐phenylenediamine hydrochloride (13652-74-9) → 2H,3H,5H,6H‐benzo[1,2‐b:5,4‐b′]dipyrrole‐2,3,5,6‐tetraone (16898-43-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium sulfate / water / 40 °C

1.2: Heating

2.1: sulfuric acid / 0.33 h / 80 °C

With sulfuric acid; sodium sulfate; In water;

DOI:10.1002/bio.3446

Reference yield:

1,3-bis-[(hydroxyimino-acetyl)-amino]-benzene (38085-55-1) → 2H,3H,5H,6H‐benzo[1,2‐b:5,4‐b′]dipyrrole‐2,3,5,6‐tetraone (16898-43-4)

Guidance literature:

With sulfuric acid;

upstream raw materials:

1,3-bis-[(hydroxyimino-acetyl)-amino]-benzene

m-phenylenediamine

m‐phenylenediamine hydrochloride

Downstream raw materials:

2,8-diphenylpyrido[3,2-g]quinoline-4,6-dicarboxylicacid