t-butyl 2-(4-((2-(4-nitrophenyl)-2-oxoethyl)carbamoyl)cyclohexyl)acetate

Base Information

Chemical Name:t-butyl 2-(4-((2-(4-nitrophenyl)-2-oxoethyl)carbamoyl)cyclohexyl)acetate
CAS No.:1363365-33-6
Molecular Formula:C₂₁H₂₈N₂O₆
Molecular Weight:404.463
Hs Code.:

Synonyms:t-butyl 2-(4-((2-(4-nitrophenyl)-2-oxoethyl)carbamoyl)cyclohexyl)acetate

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Chemical Property of t-butyl 2-(4-((2-(4-nitrophenyl)-2-oxoethyl)carbamoyl)cyclohexyl)acetate

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Technology Process of t-butyl 2-(4-((2-(4-nitrophenyl)-2-oxoethyl)carbamoyl)cyclohexyl)acetate

There total 7 articles about t-butyl 2-(4-((2-(4-nitrophenyl)-2-oxoethyl)carbamoyl)cyclohexyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 218779-78-3
4-(2-(tert-butoxy)-2-oxoethyl)cyclohexanecarboxylic acid

: 5425-81-0
2-amino-1-(4-nitrophenyl)ethanone hydrochloride

: 1363365-33-6
t-butyl 2-(4-((2-(4-nitrophenyl)-2-oxoethyl)carbamoyl)cyclohexyl)acetate

Guidance literature:: 4-(2-(tert-butoxy)-2-oxoethyl)cyclohexanecarboxylic acid; 2-amino-1-(4-nitrophenyl)ethanone hydrochloride; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

With triethylamine; In N,N-dimethyl-formamide; at 60 ℃; for 16h;

Reference yield:

: 27784-76-5
tert-butyl diethylphosphonoacetate

: 1363365-33-6
t-butyl 2-(4-((2-(4-nitrophenyl)-2-oxoethyl)carbamoyl)cyclohexyl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C

1.2: 16 h / 20 °C

2.1: hydrogen / palladium on activated charcoal / ethyl acetate / 3 h / 20 °C / 2585.81 Torr

3.1: potassium hydroxide; water / methanol / 16 h / 20 °C

3.2: pH 1

4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.08 h / 20 °C

4.2: 16 h / 60 °C

With water; hydrogen; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; potassium hydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 100-19-6
(4-nitrophenyl)ethanone

: 1363365-33-6
t-butyl 2-(4-((2-(4-nitrophenyl)-2-oxoethyl)carbamoyl)cyclohexyl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromine / aluminum (III) chloride / 0.67 h

2.1: hexamethylenetetramine / dichloromethane / 1 h

2.2: 51 h

3.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.08 h / 20 °C

3.2: 16 h / 60 °C

With hexamethylenetetramine; bromine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; aluminum (III) chloride; In dichloromethane; N,N-dimethyl-formamide;