Technology Process of benzyl (4-(difluoromethyl)bicycio[2.2,2]octan-1-yl)carbamate
There total 7 articles about benzyl (4-(difluoromethyl)bicycio[2.2,2]octan-1-yl)carbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
diethylamino-sulfur trifluoride;
In
dichloromethane;
at 20 ℃;
for 2h;
- Guidance literature:
-
4-(difluoromethyl)bicyclo[2.2.2]octane-1-carboxylic acid;
With
diphenyl phosphoryl azide; triethylamine;
In
toluene;
at 20 ℃;
for 2h;
Reflux;
benzyl alcohol;
In
toluene;
for 18h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: diphenyl phosphoryl azide; triethylamine / toluene / 2 h / 20 - 110 °C
1.2: 16 h / 110 °C
2.1: sodium hydroxide; water / methanol / 2 h / 65 °C
3.1: borane-THF / tetrahydrofuran / 2 h / 0 - 20 °C
4.1: pyridinium chlorochromate / dichloromethane / 2 h / 0 - 20 °C
5.1: diethylamino-sulfur trifluoride / dichloromethane / 2 h / 0 - 20 °C
With
borane-THF; diethylamino-sulfur trifluoride; diphenyl phosphoryl azide; water; triethylamine; pyridinium chlorochromate; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
![benzyl (4-formylbicyclo[2,2.2]octan-1-yl)carbamate](/Databaselist/images/loading.webp)
