(E)-3-{1-[2-(1-Benzyl-cyclohex-2-enyl)-acetyl]-5-benzyloxy-1H-indol-3-yl}-acrylic acid allyl ester

Base Information

Chemical Name:(E)-3-{1-[2-(1-Benzyl-cyclohex-2-enyl)-acetyl]-5-benzyloxy-1H-indol-3-yl}-acrylic acid allyl ester
CAS No.:103580-97-8
Molecular Formula:C₃₆H₃₅NO₄
Molecular Weight:545.678
Hs Code.:

Synonyms:(E)-3-{1-[2-(1-Benzyl-cyclohex-2-enyl)-acetyl]-5-benzyloxy-1H-indol-3-yl}-acrylic acid allyl ester

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Chemical Property of (E)-3-{1-[2-(1-Benzyl-cyclohex-2-enyl)-acetyl]-5-benzyloxy-1H-indol-3-yl}-acrylic acid allyl ester

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Technology Process of (E)-3-{1-[2-(1-Benzyl-cyclohex-2-enyl)-acetyl]-5-benzyloxy-1H-indol-3-yl}-acrylic acid allyl ester

There total 2 articles about (E)-3-{1-[2-(1-Benzyl-cyclohex-2-enyl)-acetyl]-5-benzyloxy-1H-indol-3-yl}-acrylic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103581-94-8
methyl (E)-3-<5-(benzyloxy)-1H-indol-3-yl>-2-propenoate

: 103580-97-8
(E)-3-{1-[2-(1-Benzyl-cyclohex-2-enyl)-acetyl]-5-benzyloxy-1H-indol-3-yl}-acrylic acid allyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 75.1 percent / toluene / 20 h / Heating

2: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, 0.5 h

With sodium hydride; In toluene;
DOI:10.1021/jm00083a004

Reference yield:

: (1-Benzyl-cyclohex-2-enyl)-acetyl chloride

: 103580-91-2
allyl (E)-3-<5-(benzyloxy)-1H-indol-3-yl>-2-propenoate

: 103580-97-8
(E)-3-{1-[2-(1-Benzyl-cyclohex-2-enyl)-acetyl]-5-benzyloxy-1H-indol-3-yl}-acrylic acid allyl ester

Guidance literature:: With sodium hydride; Multistep reaction; 1.) DMF, RT, 30 min, 2.) DMF, 0.5 h;
DOI:10.1021/jm00083a004

Reference yield:

: 103580-97-8
(E)-3-{1-[2-(1-Benzyl-cyclohex-2-enyl)-acetyl]-5-benzyloxy-1H-indol-3-yl}-acrylic acid allyl ester

: 103558-41-4
(3aR,4R,11aS,11bR)-4-Amino-11a-benzyl-7-hydroxy-2,3,3a,4,5,11,11a,11b-octahydro-1H-9b-aza-benzo[cd]fluoranthen-10-one

Guidance literature:: Multi-step reaction with 7 steps

1: 2.) 15percent ethanol. HCl / 1.) mesitylene, reflux, 12 h, 2.) mesitylene, reflux, 0.5 h

2: tetrakis(triphenylphosphine)palladium⁽⁰⁾, Et₃N, 2-ethylhexanoic acid / ethyl acetate; CHCl₃ / 8 h / Ambient temperature

3: ethyl chloroformate, Et₃N / acetone / 0.5 h

4: NaN₃ / acetone; H₂O / 0.5 h / 0 °C

5: xylene / 0.5 h / Heating

6: xylene / 1 h / Heating

7: H₂ / 10percent Pd/C / dimethylformamide / 760 Torr / Ambient temperature

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; 2-Ethylhexanoic acid; hydrogen; chloroformic acid ethyl ester; triethylamine; palladium on activated charcoal; In chloroform; water; ethyl acetate; N,N-dimethyl-formamide; acetone; xylene;
DOI:10.1021/jm00083a004