1-(2-(4-Fluorophenoxy)phenyl)-N-methylmethanamine

Base Information

• Chemical Name: 1-(2-(4-Fluorophenoxy)phenyl)-N-methylmethanamine
• CAS No.: 833482-53-4
• Molecular Formula: C₁₄H₁₄FNO
• Molecular Weight: 231.27
• DSSTox Substance ID: DTXSID20439636
• Mol file: 833482-53-4.mol

Synonyms:833482-53-4;1-(2-(4-Fluorophenoxy)phenyl)-N-methylmethanamine;1-[2-(4-FLUOROPHENOXY)PHENYL]-N-METHYLMETHYLAMINE;2-(4-Fluorophenoxy)-N-methylbenzylamine;1-[2-(4-Fluorophenoxy)phenyl]-N-methylmethanamine;(2-(4-Fluorophenoxy)phenyl)-N-methylmethanamine;SCHEMBL20852556;DTXSID20439636;AKOS009426495;SB81108;CS-0326320;N-[2-(4-Fluorophenoxy)benzyl]-N-methylamine, AldrichCPR

Chemical Property of 1-(2-(4-Fluorophenoxy)phenyl)-N-methylmethanamine

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.553
• Boiling Point: 299.509°C at 760 mmHg
• Flash Point: 134.938°C
• PSA: 21.26000
• Density: 1.123g/cm³
• LogP: 3.72830
• Storage Temp.: 2-8°C
• Sensitive.: Air Sensitive
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 231.105942232
• Heavy Atom Count: 17
• Complexity: 216

Purity/Quality:

99% ^*data from raw suppliers

1-[2-(4-Fluorophenoxy)phenyl]-N-methylmethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNCC1=CC=CC=C1OC2=CC=C(C=C2)F
• Uses: 2-(4-Fluorophenoxy)-N-methylbenzylamine is used as pharmaceutical-intermediates.

Technology Process of 1-(2-(4-Fluorophenoxy)phenyl)-N-methylmethanamine

There total 3 articles about 1-(2-(4-Fluorophenoxy)phenyl)-N-methylmethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-fluorophenoxy)-N-methylbenzamide → 2-(4-fluorophenoxy)-N-methylbenzylamine (833482-53-4)

Guidance literature:

With borane-THF; In tetrahydrofuran; for 2h; Heating;

DOI:10.1002/jlcr.828

Reference yield:

4-Fluorophenol (371-41-5) → 2-(4-fluorophenoxy)-N-methylbenzylamine (833482-53-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / caesium carbonate; tetrakis(acetonitrile)copper(I) hexafluorophosphate / toluene / 12 h / Heating

2: BH₃*THF / tetrahydrofuran / 2 h / Heating

With borane-THF; tetrakis(acetonitrile)copper(I) hexafluorophosphate; caesium carbonate; In tetrahydrofuran; toluene; 1: Ullmann ether synthesis;

DOI:10.1002/jlcr.828

Reference yield:

2-bromo-N-methylbenzamide (61436-88-2) → 2-(4-fluorophenoxy)-N-methylbenzylamine (833482-53-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / caesium carbonate; tetrakis(acetonitrile)copper(I) hexafluorophosphate / toluene / 12 h / Heating

2: BH₃*THF / tetrahydrofuran / 2 h / Heating

With borane-THF; tetrakis(acetonitrile)copper(I) hexafluorophosphate; caesium carbonate; In tetrahydrofuran; toluene; 1: Ullmann ether synthesis;

DOI:10.1002/jlcr.828

upstream raw materials:

4-Fluorophenol

2-bromo-N-methylbenzamide