6-(6-amino-5-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}pyridin-3-yl)-2,3-dihydro-1-benzothiophene-3-ol-1,1-dioxide

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Chemical Name:6-(6-amino-5-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}pyridin-3-yl)-2,3-dihydro-1-benzothiophene-3-ol-1,1-dioxide
CAS No.:1346816-62-3
Molecular Formula:C₂₃H₂₀FN₅O₄S
Molecular Weight:481.507
Hs Code.:

Synonyms:6-(6-amino-5-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}pyridin-3-yl)-2,3-dihydro-1-benzothiophene-3-ol-1,1-dioxide

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Chemical Property of 6-(6-amino-5-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}pyridin-3-yl)-2,3-dihydro-1-benzothiophene-3-ol-1,1-dioxide

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Technology Process of 6-(6-amino-5-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}pyridin-3-yl)-2,3-dihydro-1-benzothiophene-3-ol-1,1-dioxide

There total 4 articles about 6-(6-amino-5-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}pyridin-3-yl)-2,3-dihydro-1-benzothiophene-3-ol-1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.4%

: 1346818-94-7
6-bromo-2,3-dihydrobenzo[b]thiophen-3-ol-1,1-dioxide

: 1346819-57-5
3-[(R)-1-(5-fluoro-2-[1,2,3]triazol-2-ylphenyl)ethoxy]-5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyridin-2-ylamine

: 1346816-62-3
6-(6-amino-5-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}pyridin-3-yl)-2,3-dihydro-1-benzothiophene-3-ol-1,1-dioxide

Guidance literature:: With cesium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In methanol; at 120 ℃; for 1h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 773134-43-3
methyl 4-bromo-2-(methylsulfonyl)benzoate

: 1346816-62-3
6-(6-amino-5-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}pyridin-3-yl)-2,3-dihydro-1-benzothiophene-3-ol-1,1-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 5 h / 20 °C

2.1: sodium tetrahydroborate / dichloromethane; methanol / 1.5 h / 0 - 20 °C

2.2: 0 °C

3.1: cesium fluoride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / methanol / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

With sodium tetrahydroborate; sodium hydride; cesium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; dichloromethane; mineral oil;

Reference yield:

: 1240288-81-6
6-bromo-1-benzothiophen-3(2H)-one 1,1-dioxide

: 1346816-62-3
6-(6-amino-5-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}pyridin-3-yl)-2,3-dihydro-1-benzothiophene-3-ol-1,1-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / dichloromethane; methanol / 1.5 h / 0 - 20 °C

1.2: 0 °C

2.1: cesium fluoride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / methanol / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

With sodium tetrahydroborate; cesium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In methanol; dichloromethane;