2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide

Base Information

Chemical Name:2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide
CAS No.:415687-81-9
Molecular Formula:C₁₆H₁₆BrN₃O
Molecular Weight:346.227
Hs Code.:
European Community (EC) Number:809-324-4
ChEMBL ID:CHEMBL3264401
Mol file:415687-81-9.mol

Synonyms:415687-81-9;CHEMBL3264401;1-[(E)-(4-Bromophenyl)methylideneamino]-3-(2,6-dimethylphenyl)urea;EGA;2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide;SCHEMBL15880193;SCHEMBL15880195;BDBM50010576;AKOS037643447;AKOS040746794;AS-16461;HY-125168;CS-0089743;A900596

Suppliers and Price of 2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
EGA
5mg
$ 165.00

Sigma-Aldrich
EGA ≥98% (HPLC)
25mg
$ 399.00

Sigma-Aldrich
EGA ≥98% (HPLC)
5mg
$ 101.00

Cayman Chemical
EGA
10mg
$ 136.00

Cayman Chemical
EGA
5mg
$ 96.00

Cayman Chemical
EGA
1mg
$ 28.00

Cayman Chemical
EGA
25mg
$ 305.00

AK Scientific
EGA
50mg
$ 560.00

Total 5 raw suppliers

Chemical Property of 2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide

Chemical Property:

Storage Temp.:2-8°C
Solubility.:DMSO: soluble5mg/vial, clear (warmed)
XLogP3:4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:345.04767
Heavy Atom Count:21
Complexity:357

Purity/Quality:

97% ^*data from raw suppliers

EGA ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi,N
Statements: 36/37/38-50/53
Safety Statements: 26-36/37/39-60-61

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C(=CC=C1)C)NC(=O)NN=CC2=CC=C(C=C2)Br
Isomeric SMILES:CC1=C(C(=CC=C1)C)NC(=O)N/N=C/C2=CC=C(C=C2)Br
Description EGA (415687-81-9) is a novel selective inhibitor of endosomal trafficking which blocks cellular entry of lethal toxin and other acid-dependent bacterial toxins and viruses into mammalian cells.1?Inhibits Anthrax lethal toxin-induced RAW264.7 cell death, IC50=1.7 mM.1 Delays lysosomal targeting and degradation of the EGF receptor indicating that it targets host membrane trafficking.1 Does not block endosomal recycling of transferrin, retrograde trafficking of ricin, phagolysosomal trafficking or phagosome permeabilization by Franciscella tularensis, nor does it neutralize acidic organelles.1 Protects mammalian cells from Clostridium difficile CDT, Clostridium perfringens Iota toxin and Clostridium botulinum C2 toxin.2 A useful tool for exploring subcellular trafficking of various bacterial toxins.3
Uses EGA is a selective inhibitor of endosomol trafficking pathways exploited by multiple toxins and viruses.

Technology Process of 2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide

There total 3 articles about 2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 171277-86-4
N-(2,6-dimethylphenyl)semicarbazide

: 1122-91-4
4-bromo-benzaldehyde

: 415687-81-9
N¹-(4-bromobenzylidene)-N⁴-(2,6-dimethylphenyl)semicarbazone

Guidance literature:: With acetic acid; In ethanol; for 0.166667h; Reflux;

Reference yield:

: 39143-76-5
phenyl-N-(2,6-dimethylphenyl)carbamate

: 415687-81-9
N¹-(4-bromobenzylidene)-N⁴-(2,6-dimethylphenyl)semicarbazone

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / dichloromethane / 20 °C

2: acetic acid / ethanol / 0.17 h / Reflux

With hydrazine hydrate; acetic acid; In ethanol; dichloromethane;

Reference yield:

: 87-62-7
2,6-dimethylaniline

: 415687-81-9
N¹-(4-bromobenzylidene)-N⁴-(2,6-dimethylphenyl)semicarbazone

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 2 h / 20 °C / Cooling with ice

2: hydrazine hydrate / dichloromethane / 20 °C

3: acetic acid / ethanol / 0.17 h / Reflux

With hydrazine hydrate; acetic acid; triethylamine; In ethanol; dichloromethane;