(7E,9E,11E,13E)-(5S,6R,15S)-5,6,15-Trihydroxy-icosa-7,9,11,13-tetraenoic acid

Base Information

• Chemical Name: (7E,9E,11E,13E)-(5S,6R,15S)-5,6,15-Trihydroxy-icosa-7,9,11,13-tetraenoic acid
• CAS No.: 94292-83-8
• Molecular Formula: C₂₀H₃₂O₅
• Molecular Weight: 352.471
• Mol file: 94292-83-8.mol

Synonyms:(7E,9E,11E,13E)-(5S,6R,15S)-5,6,15-Trihydroxy-icosa-7,9,11,13-tetraenoic acid

Chemical Property of (7E,9E,11E,13E)-(5S,6R,15S)-5,6,15-Trihydroxy-icosa-7,9,11,13-tetraenoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (7E,9E,11E,13E)-(5S,6R,15S)-5,6,15-Trihydroxy-icosa-7,9,11,13-tetraenoic acid

There total 19 articles about (7E,9E,11E,13E)-(5S,6R,15S)-5,6,15-Trihydroxy-icosa-7,9,11,13-tetraenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

epi-lipoxin A4 (94235-42-4) → lipoxin A4 (89663-86-5,171030-11-8) + (7E,9E,11E,13E)-(5S,6R,15S)-5,6,15-Trihydroxy-icosa-7,9,11,13-tetraenoic acid (94292-83-8,171030-11-8) + 6S-Lipoxin A4 (94292-80-5,171030-11-8) + (7E,9E,11E,13E)-(5S,6S,15S)-5,6,15-Trihydroxy-icosa-7,9,11,13-tetraenoic acid (94292-84-9,171030-11-8)

Guidance literature:

With water; Further byproducts given;

DOI:10.1016/S0040-4039(00)96323-8

Reference yield:

4-[(2R,3R)-3-((1E,3E,5E,7E)-(S)-9-Hydroxy-tetradeca-1,3,5,7-tetraenyl)-oxiranyl]-butyric acid ethyl ester (94235-41-3,95341-54-1) → (7E,9E,11E,13E)-(5R,6S,15R)-5,6,15-Trihydroxy-icosa-7,9,11,13-tetraenoic acid (89663-86-5,94292-80-5,94292-82-7,94292-83-8,94292-84-9,94292-86-1,95341-55-2,119720-62-6,120442-99-1,121842-52-2,171030-11-8) + (7E,9E,11E,13E)-(5S,6R,15R)-5,6,15-Trihydroxy-icosa-7,9,11,13-tetraenoic acid (89663-86-5,94292-80-5,94292-82-7,94292-83-8,94292-84-9,94292-86-1,95341-55-2,119720-62-6,120442-99-1,121842-52-2,171030-11-8)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 60 ℃; for 2h;

DOI:10.1016/S0040-4039(01)81500-8

Reference yield:

4-[(2R,3R)-3-((1E,3E,5E,7E)-(S)-9-Hydroxy-tetradeca-1,3,5,7-tetraenyl)-oxiranyl]-butyric acid ethyl ester (94235-41-3,95341-54-1) → (7E,9E,11E,13E)-(5R,6S,15R)-5,6,15-Trihydroxy-icosa-7,9,11,13-tetraenoic acid (89663-86-5,94292-80-5,94292-82-7,94292-83-8,94292-84-9,94292-86-1,95341-55-2,119720-62-6,120442-99-1,121842-52-2,171030-11-8) + (7E,9E,11E,13E)-(5S,6R,15R)-5,6,15-Trihydroxy-icosa-7,9,11,13-tetraenoic acid (89663-86-5,94292-80-5,94292-82-7,94292-83-8,94292-84-9,94292-86-1,95341-55-2,119720-62-6,120442-99-1,121842-52-2,171030-11-8)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 60 ℃; for 2h;

DOI:10.1016/S0040-4039(01)81500-8

upstream raw materials:

(5S,6R,15S)-(7E,9E,11E,13E)-5,6-O-carbonyl lipoxin A₄ ethyl ester

5S-hydroxy-14,15-LTA₄

epi-lipoxin A₄

2-deoxy-D-ribose