(7R)-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxamide

Base Information

Chemical Name:(7R)-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxamide
CAS No.:1234620-22-4
Molecular Formula:C₂₀H₁₄F₃N₇O
Molecular Weight:425.373
Hs Code.:

Synonyms:(7R)-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxamide

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Chemical Property of (7R)-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxamide

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Technology Process of (7R)-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxamide

There total 6 articles about (7R)-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1234620-20-2
(7R)-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylic acid

: 1234620-22-4
(7R)-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxamide

Guidance literature:: With ammonium chloride; triethylamine; HATU; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 12h; Inert atmosphere;

Reference yield:

: 1234620-16-6
ethyl (rac)-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate

: 1234620-22-4
(7R)-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: Daicel Chiralpak IB / tert-butyl methyl ether; methanol / 30 °C / Resolution of racemate

2.1: water; lithium hydroxide / ethanol; tetrahydrofuran / 1.5 h / 55 °C / Inert atmosphere

2.2: 0 °C

3.1: triethylamine; ammonium chloride; HATU / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

With water; ammonium chloride; triethylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; tert-butyl methyl ether; N,N-dimethyl-formamide;

Reference yield:

: 1234620-18-8
ethyl (7R)-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate

: 1234620-22-4
(7R)-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / ethanol; tetrahydrofuran / 1.5 h / 55 °C / Inert atmosphere

1.2: 0 °C

2.1: triethylamine; ammonium chloride; HATU / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

With water; ammonium chloride; triethylamine; HATU; lithium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;