(8α,13α,14β,17β)-3-methoxyestra-1,3,5(10),9(11)-tetraen-17-ol p-nitrobenzoate

Base Information

Chemical Name:(8α,13α,14β,17β)-3-methoxyestra-1,3,5(10),9(11)-tetraen-17-ol p-nitrobenzoate
CAS No.:428439-30-9
Molecular Formula:C₂₆H₂₇NO₅
Molecular Weight:433.504
Hs Code.:

Synonyms:(8α,13α,14β,17β)-3-methoxyestra-1,3,5(10),9(11)-tetraen-17-ol p-nitrobenzoate

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Chemical Property of (8α,13α,14β,17β)-3-methoxyestra-1,3,5(10),9(11)-tetraen-17-ol p-nitrobenzoate

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Technology Process of (8α,13α,14β,17β)-3-methoxyestra-1,3,5(10),9(11)-tetraen-17-ol p-nitrobenzoate

There total 9 articles about (8α,13α,14β,17β)-3-methoxyestra-1,3,5(10),9(11)-tetraen-17-ol p-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 108267-88-5
(8α,13α,14β,17α)-3-methoxyestra-1,3,5(10),9(11)-tetraen-17-ol

: 62-23-7
4-nitro-benzoic acid

: 428439-30-9
(8α,13α,14β,17β)-3-methoxyestra-1,3,5(10),9(11)-tetraen-17-ol p-nitrobenzoate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In toluene; at 80 ℃; for 6h;
DOI:10.1016/j.steroids.2006.12.007

Reference yield:

: 428439-23-0
(1R,7aR)-1-(1,1-dimethylethoxy)-1,2,3,6,7,7a-hexahydro-4-[2-(3-methoxyphenyl)ethyl]-7a-methyl-5H-inden-5-one

: 428439-30-9
(8α,13α,14β,17β)-3-methoxyestra-1,3,5(10),9(11)-tetraen-17-ol p-nitrobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 52 percent / H₂ / Pd/C / ethanol / 1 h / 2584.17 Torr

2: 72 percent / aq. HCl / methanol / 8 h / 0 - 20 °C

3: TiCl₄ / CH₂Cl₂ / 0.25 h / -10 °C

4: 41 percent / PPh₃; DEAD / toluene / 6 h / 80 °C

With hydrogenchloride; hydrogen; titanium tetrachloride; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In methanol; ethanol; dichloromethane; toluene;
DOI:10.1016/j.steroids.2006.12.007

Reference yield:

: 5020-41-7
2-(3-methoxyphenyl)-ethanol

: 428439-30-9
(8α,13α,14β,17β)-3-methoxyestra-1,3,5(10),9(11)-tetraen-17-ol p-nitrobenzoate

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / pyridine / 0 - 5 °C

2: 60 percent / NaH / 1,2-dimethoxy-ethane / 40 h / 65 °C

3: 52 percent / H₂ / Pd/C / ethanol / 1 h / 2584.17 Torr

4: 72 percent / aq. HCl / methanol / 8 h / 0 - 20 °C

5: TiCl₄ / CH₂Cl₂ / 0.25 h / -10 °C

6: 41 percent / PPh₃; DEAD / toluene / 6 h / 80 °C

With pyridine; hydrogenchloride; hydrogen; titanium tetrachloride; sodium hydride; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; toluene;
DOI:10.1016/j.steroids.2006.12.007