ANTI-EAPII (TTRAP)

Base Information

• Chemical Name: ANTI-EAPII (TTRAP)
• CAS No.: 828934-41-4
• Molecular Formula: C15H19 Cl O4 . Na
• Molecular Weight: 322.76
• Hs Code.: 2918999090
• Mol file: 828934-41-4.mol

Synonyms:Oxiranecarboxylicacid, 2-[6-(4-chlorophenoxy)hexyl]-, sodium salt, (2R)- (9CI)

Chemical Property of ANTI-EAPII (TTRAP)

Chemical Property:

• PSA: 61.89000
• LogP: 2.18820
• Storage Temp.: 2-8°C
• Solubility.: H2O: freely soluble

Purity/Quality:

99% ^*data from raw suppliers

(2R)-2-[6-(4-Chlorophenoxy)hexyl]-oxiranecarboxylicAcidSodiumSalt ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Description: (R)-(+)-Etomoxir sodium salt is R-form of Etomoxir sodium salt. Etomoxir is a potent inhibitor of carnitine palmitoyltransferase-I (CPT-1). Etomoxir Na (828934-41-4) is an irreversible inhibitor of mitochondrial carnitine palmitoyl transferase 1 (CPT1).1 It is widely used to study fatty acid oxidation. Etomoxir has been investigated as a therapeutic agent for heart disease2, diabetes3, and cancer4,5. Use of etomoxir in concentrations greater than 5 μM induces acute production of ROS with associated evidence of severe oxidative stress in proliferating T cells indicating a loss of specificity for CTP1 at these concentrations.6 200 μM etomoxir inhibited complex I of the electron transport chain.7
• Uses: (+)-Etomoxir sodium salt hydrate has been used as an inhibitor of carnitine palmitoyltransferase 1 (CPT-1) in breast tumor cell lines and mice tumor. It has also been used as an inhibitor of fatty acid oxidation in human primary prostate epithelial cells and lymphocytes.