1-(3,4-diamino-5-(3-fluorophenyl)pyridin-2-yl)piperidine-3-carboxamide

Base Information

Chemical Name:1-(3,4-diamino-5-(3-fluorophenyl)pyridin-2-yl)piperidine-3-carboxamide
CAS No.:1600524-53-5
Molecular Formula:C₁₇H₂₀FN₅O
Molecular Weight:329.377
Hs Code.:

Synonyms:1-(3,4-diamino-5-(3-fluorophenyl)pyridin-2-yl)piperidine-3-carboxamide

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Chemical Property of 1-(3,4-diamino-5-(3-fluorophenyl)pyridin-2-yl)piperidine-3-carboxamide

Chemical Property:

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Technology Process of 1-(3,4-diamino-5-(3-fluorophenyl)pyridin-2-yl)piperidine-3-carboxamide

There total 5 articles about 1-(3,4-diamino-5-(3-fluorophenyl)pyridin-2-yl)piperidine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 800402-12-4
2-chloro-4-amino-5-iodopyridine

: 1600524-53-5
1-(3,4-diamino-5-(3-fluorophenyl)pyridin-2-yl)piperidine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid; nitric acid / 4 h / 20 °C / Cooling with ice

2: 1,4-dioxane; water / 6 h / 120 °C / Inert atmosphere; Sealed tube

3: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,2-dimethoxyethane / 3 h / 120 °C / Inert atmosphere; Schlenk technique; Sealed tube

4: palladium 10% on activated carbon; hydrogen / ethanol; tetrahydrofuran / 2 h / 20 °C / 2068.65 Torr / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; palladium 10% on activated carbon; hydrogen; nitric acid; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water; 3: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2014.03.019

Reference yield:

: 14432-12-3
4-Amino-2-chloropyridine

: 1600524-53-5
1-(3,4-diamino-5-(3-fluorophenyl)pyridin-2-yl)piperidine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium acetate; Iodine monochloride / acetic acid / 4 h / 70 °C / Inert atmosphere

2: sulfuric acid; nitric acid / 4 h / 20 °C / Cooling with ice

3: 1,4-dioxane; water / 6 h / 120 °C / Inert atmosphere; Sealed tube

4: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,2-dimethoxyethane / 3 h / 120 °C / Inert atmosphere; Schlenk technique; Sealed tube

5: palladium 10% on activated carbon; hydrogen / ethanol; tetrahydrofuran / 2 h / 20 °C / 2068.65 Torr / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; palladium 10% on activated carbon; hydrogen; nitric acid; potassium acetate; Iodine monochloride; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water; acetic acid; 4: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2014.03.019

Reference yield:

: 1600524-47-7
2-chloro-5-iodo-3-nitropyridin-4-amine

: 1600524-53-5
1-(3,4-diamino-5-(3-fluorophenyl)pyridin-2-yl)piperidine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1,4-dioxane; water / 6 h / 120 °C / Inert atmosphere; Sealed tube

2: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,2-dimethoxyethane / 3 h / 120 °C / Inert atmosphere; Schlenk technique; Sealed tube

3: palladium 10% on activated carbon; hydrogen / ethanol; tetrahydrofuran / 2 h / 20 °C / 2068.65 Torr / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water; 2: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2014.03.019