(R)-2-phenyl-2-phenylcarbamoylpyrrolidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(R)-2-phenyl-2-phenylcarbamoylpyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:1364782-68-2
Molecular Formula:C₂₂H₂₆N₂O₃
Molecular Weight:366.46
Hs Code.:

Synonyms:(R)-2-phenyl-2-phenylcarbamoylpyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Property of (R)-2-phenyl-2-phenylcarbamoylpyrrolidine-1-carboxylic acid tert-butyl ester

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Technology Process of (R)-2-phenyl-2-phenylcarbamoylpyrrolidine-1-carboxylic acid tert-butyl ester

There total 4 articles about (R)-2-phenyl-2-phenylcarbamoylpyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 103-71-9
phenyl isocyanate

: 174311-02-5
2-phenylpyrrolidine-1-carboxylic acid tert-butyl ester

: 1364782-68-2
(R)-2-phenyl-2-phenylcarbamoylpyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: 2-phenylpyrrolidine-1-carboxylic acid tert-butyl ester; With n-butyllithium; In tetrahydrofuran; hexane; at -50 ℃; for 0.0833333h; Inert atmosphere;

phenyl isocyanate; In tetrahydrofuran; hexane; at -50 ℃; for 0.166667h; optical yield given as %ee; Inert atmosphere;
DOI:10.1021/ja211398b

Reference yield:

: 62-53-3
aniline

: 1-(tert-butoxycarbonyl)-2-phenylpyrrolidine-2-carboxylic acid

: 1364782-63-7
(S)-2-phenyl-2-phenylcarbamoylpyrrolidine-1-carboxylic acid tert-butyl ester

: 1364782-68-2
(R)-2-phenyl-2-phenylcarbamoylpyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h; optical yield given as %ee; Inert atmosphere;
DOI:10.1021/ja211398b

Reference yield:

: C₁₅H₂₀LiNO₂

: 1364782-63-7
(S)-2-phenyl-2-phenylcarbamoylpyrrolidine-1-carboxylic acid tert-butyl ester

: 1364782-68-2
(R)-2-phenyl-2-phenylcarbamoylpyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / 0 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With n-butyllithium; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/ja211398b