(1'S,2'S,3'R)-1-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}-N⁴-(N,N-dimethylaminomethylene)cytosine

Base Information

• Chemical Name: (1'S,2'S,3'R)-1-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}-N⁴-(N,N-dimethylaminomethylene)cytosine
• CAS No.: 283598-25-4
• Molecular Formula: C₃₄H₃₈N₄O₅
• Molecular Weight: 582.7

Synonyms:(1'S,2'S,3'R)-1-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}-N⁴-(N,N-dimethylaminomethylene)cytosine

Chemical Property of (1'S,2'S,3'R)-1-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}-N⁴-(N,N-dimethylaminomethylene)cytosine

Chemical Property:

Purity/Quality:

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Useful:

Technology Process of (1'S,2'S,3'R)-1-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}-N⁴-(N,N-dimethylaminomethylene)cytosine

There total 4 articles about (1'S,2'S,3'R)-1-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}-N⁴-(N,N-dimethylaminomethylene)cytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N,N-dimethyl-formamide dimethyl acetal (4637-24-5) + (1'S,2'S,3'R)-1-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}cytosine (283598-16-3) → (1'S,2'S,3'R)-1-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}-N4-(N,N-dimethylaminomethylene)cytosine (283598-25-4)

Guidance literature:

In methanol; at 20 ℃; for 12h;

DOI:10.1016/S0040-4020(00)00162-9

Reference yield:

<1R-(1α,2β,3β)>-3-<<(4-methylphenyl)sulfonyl>oxy>-1,2-cyclobutanedimethanol dibenzoate ester (132294-26-9) → (1'S,2'S,3'R)-1-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}-N4-(N,N-dimethylaminomethylene)cytosine (283598-25-4)

Guidance literature:

Multi-step reaction with 4 steps

2.1: Et₃N / H₂O; methanol / 12 h / 20 °C

2.2: 86 percent / Py / 12 h / 20 °C

3.1: 43 percent / AcOH / methanol; CHCl₃ / 3 h / 20 °C

4.1: 84 percent / methanol / 12 h / 20 °C

With acetic acid; triethylamine; In methanol; chloroform; water; 2.1: Hydrolysis / 2.2: Substitution / 3.1: Substitution / 4.1: Condensation;

DOI:10.1016/S0040-4020(00)00162-9

Reference yield:

(1'S,2'S,3'R)-1-[2',3'-bis(benzoyloxymethyl)cyclobutyl]-N4-benzoylcytosine (283598-01-6) → (1'S,2'S,3'R)-1-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}-N4-(N,N-dimethylaminomethylene)cytosine (283598-25-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Et₃N / H₂O; methanol / 12 h / 20 °C

1.2: 86 percent / Py / 12 h / 20 °C

2.1: 43 percent / AcOH / methanol; CHCl₃ / 3 h / 20 °C

3.1: 84 percent / methanol / 12 h / 20 °C

With acetic acid; triethylamine; In methanol; chloroform; water; 1.1: Hydrolysis / 1.2: Substitution / 2.1: Substitution / 3.1: Condensation;

DOI:10.1016/S0040-4020(00)00162-9

upstream raw materials:

N,N-dimethyl-formamide dimethyl acetal

(1'S,2'S,3'R)-1-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}cytosine

<1R-(1α,2β,3β)>-3-<<(4-methylphenyl)sulfonyl>oxy>-1,2-cyclobutanedimethanol dibenzoate ester

(1'S,2'S,3'R)-1-[2',3'-bis(benzoyloxymethyl)cyclobutyl]-N⁴-benzoylcytosine

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