N-((2S,4S,5S)-5-(dibenzylamino)-4-hydroxy-1,6-diphenylhexan-2-yl)-2-(2,6-dimethylphenoxy)acetamide

Base Information

• Chemical Name: N-((2S,4S,5S)-5-(dibenzylamino)-4-hydroxy-1,6-diphenylhexan-2-yl)-2-(2,6-dimethylphenoxy)acetamide
• CAS No.: 898254-22-3
• Molecular Formula: C₄₂H₄₆N₂O₃
• Molecular Weight: 626.839
• Mol file: 898254-22-3.mol

Synonyms:N-((2S,4S,5S)-5-(dibenzylamino)-4-hydroxy-1,6-diphenylhexan-2-yl)-2-(2,6-dimethylphenoxy)acetamide

Chemical Property of N-((2S,4S,5S)-5-(dibenzylamino)-4-hydroxy-1,6-diphenylhexan-2-yl)-2-(2,6-dimethylphenoxy)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-((2S,4S,5S)-5-(dibenzylamino)-4-hydroxy-1,6-diphenylhexan-2-yl)-2-(2,6-dimethylphenoxy)acetamide

There total 6 articles about N-((2S,4S,5S)-5-(dibenzylamino)-4-hydroxy-1,6-diphenylhexan-2-yl)-2-(2,6-dimethylphenoxy)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(2,6-dimethylphenoxy)acetic acid (13335-71-2) + (2S,3S,5S)-2-(N,N-dibenzylamino)-3-hydroxy-5-amino-1,6-diphenylhexane (156732-15-9) → N-((2S,4S,5S)-5-(dibenzylamino)-4-hydroxy-1,6-diphenylhexan-2-yl)-2-(2,6-dimethylphenoxy)acetamide (898254-22-3)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

Reference yield:

2-(2,6-dimethylphenoxy)acetic acid (13335-71-2) → N-((2S,4S,5S)-5-(dibenzylamino)-4-hydroxy-1,6-diphenylhexan-2-yl)-2-(2,6-dimethylphenoxy)acetamide (898254-22-3)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / DMF / ethyl acetate / 6 h / 20 - 50 °C

2: aq. NaHCO₃ / ethyl acetate / 1 h / 20 °C

With thionyl chloride; sodium hydrogencarbonate; N,N-dimethyl-formamide; In ethyl acetate;

DOI:10.1021/jm070284z

Reference yield:

2,6-dimethylphenoxyacetyl chloride (20143-48-0) + (2S,3S,5S)-2-(N,N-dibenzylamino)-3-hydroxy-5-amino-1,6-diphenylhexane (156732-15-9) → N-((2S,4S,5S)-5-(dibenzylamino)-4-hydroxy-1,6-diphenylhexan-2-yl)-2-(2,6-dimethylphenoxy)acetamide (898254-22-3)

Guidance literature:

With sodium hydrogencarbonate; In ethyl acetate; at 20 ℃; for 1h;

DOI:10.1021/jm070284z

upstream raw materials:

2,6-dimethylphenoxyacetyl chloride

(2S,3S,5S)-2-(N,N-dibenzylamino)-3-hydroxy-5-amino-1,6-diphenylhexane

2-(2,6-dimethylphenoxy)acetic acid

(S,E)-5-amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one