(S)-N-(3-(2-aminopent-4-en-2-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide

Base Information

Chemical Name:(S)-N-(3-(2-aminopent-4-en-2-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide
CAS No.:1200497-16-0
Molecular Formula:C₁₃H₁₄F₄N₂O
Molecular Weight:290.261
Hs Code.:

Synonyms:(S)-N-(3-(2-aminopent-4-en-2-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-(3-(2-aminopent-4-en-2-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide

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Technology Process of (S)-N-(3-(2-aminopent-4-en-2-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide

There total 5 articles about (S)-N-(3-(2-aminopent-4-en-2-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1200497-14-8
N-(3-((S)-2-(((R)-tert-butylsulfinyl)amino)pent-4-en-2-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide

: 1200497-16-0
(S)-N-(3-(2-aminopent-4-en-2-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 2h;
DOI:10.1021/acs.jmedchem.8b00002

Reference yield:

: C₁₄H₁₆F₄N₂O₂S

: 1200497-16-0
(S)-N-(3-(2-aminopent-4-en-2-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: diethyl ether; tetrahydrofuran / 2 h / -78 °C

2.1: hydrogenchloride; ethanol / 1 h / 20 °C

2.2: pH 8 - 9

With hydrogenchloride; ethanol; In tetrahydrofuran; diethyl ether;

Reference yield:

: 1075230-62-4
(R)-2-methylpropane-2-sulfinic acid [1-(2-fluoro-5-nitrophenyl)-(E)-ethylidene]amide

: 1200497-16-0
(S)-N-(3-(2-aminopent-4-en-2-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium chloride; iron / toluene; water / 6 h / 80 °C

1.2: 0.67 h / -40 - -25 °C

2.1: tetrahydrofuran / 1 h / -78 °C

3.1: hydrogenchloride / methanol; 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; iron; ammonium chloride; In tetrahydrofuran; 1,4-dioxane; methanol; water; toluene;
DOI:10.1021/acs.jmedchem.8b00002