(S)-1-(2-(1-(chloromethyl)-5-hydroxy-2,3-dihydro-1H-benzo[e]indole-3-carbonyl)benzo[b]selenophen-5-yl)-3-(4-fluorophenyl)urea

Base Information

Chemical Name:(S)-1-(2-(1-(chloromethyl)-5-hydroxy-2,3-dihydro-1H-benzo[e]indole-3-carbonyl)benzo[b]selenophen-5-yl)-3-(4-fluorophenyl)urea
CAS No.:1429047-96-0
Molecular Formula:C₂₉H₂₁ClFN₃O₃Se
Molecular Weight:592.915
Hs Code.:

Synonyms:(S)-1-(2-(1-(chloromethyl)-5-hydroxy-2,3-dihydro-1H-benzo[e]indole-3-carbonyl)benzo[b]selenophen-5-yl)-3-(4-fluorophenyl)urea

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Chemical Property of (S)-1-(2-(1-(chloromethyl)-5-hydroxy-2,3-dihydro-1H-benzo[e]indole-3-carbonyl)benzo[b]selenophen-5-yl)-3-(4-fluorophenyl)urea

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Technology Process of (S)-1-(2-(1-(chloromethyl)-5-hydroxy-2,3-dihydro-1H-benzo[e]indole-3-carbonyl)benzo[b]selenophen-5-yl)-3-(4-fluorophenyl)urea

There total 7 articles about (S)-1-(2-(1-(chloromethyl)-5-hydroxy-2,3-dihydro-1H-benzo[e]indole-3-carbonyl)benzo[b]selenophen-5-yl)-3-(4-fluorophenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1429048-08-7
5-[3-(4-fluorophenyl)ureido]benzo[b]selenophene-2-carboxylic acid

: 128300-13-0
N²-(tert-butyloxycarbonyl)-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one

: 1429047-96-0
(S)-1-(2-(1-(chloromethyl)-5-hydroxy-2,3-dihydro-1H-benzo[e]indole-3-carbonyl)benzo[b]selenophen-5-yl)-3-(4-fluorophenyl)urea

Guidance literature:: N²-(tert-butyloxycarbonyl)-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one; With hydrogenchloride; In ethyl acetate; at -78 - 20 ℃; for 1.5h;

5-[3-(4-fluorophenyl)ureido]benzo[b]selenophene-2-carboxylic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 8.75h;
DOI:10.1039/c6ob02729f

Reference yield:

: 64150-41-0
5-nitrobenzo[b]selenophene-2-carboxylic acid ethyl ester

: 1429047-96-0
(S)-1-(2-(1-(chloromethyl)-5-hydroxy-2,3-dihydro-1H-benzo[e]indole-3-carbonyl)benzo[b]selenophen-5-yl)-3-(4-fluorophenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium on activated charcoal / ethyl acetate / 8 h / Inert atmosphere

2.1: dichloromethane / 12 h / 20 °C / Inert atmosphere

3.1: lithium hydroxide / methanol; water; tetrahydrofuran / 18 h / 23 °C

4.1: hydrogenchloride / ethyl acetate / 1.5 h / -78 - 20 °C

4.2: 8.75 h / 0 - 20 °C

With hydrogenchloride; palladium on activated charcoal; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;
DOI:10.1039/c6ob02729f

Reference yield:

: C₁₁H₁₁NO₅Se

: 1429047-96-0
(S)-1-(2-(1-(chloromethyl)-5-hydroxy-2,3-dihydro-1H-benzo[e]indole-3-carbonyl)benzo[b]selenophen-5-yl)-3-(4-fluorophenyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide / 65 °C

2.1: palladium on activated charcoal / ethyl acetate / 8 h / Inert atmosphere

3.1: dichloromethane / 12 h / 20 °C / Inert atmosphere

4.1: lithium hydroxide / methanol; water; tetrahydrofuran / 18 h / 23 °C

5.1: hydrogenchloride / ethyl acetate / 1.5 h / -78 - 20 °C

5.2: 8.75 h / 0 - 20 °C

With hydrogenchloride; palladium on activated charcoal; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1039/c6ob02729f