tert-butyl 3-{[((5R)-3-{4-[amino(imino)methyl]phenyl}-4,5-dihydro-5-isoxazolyl)acetyl]amino}-N-((3R)-3-{[tert-butyl(dimethyl)silyl]oxy}butoxycarbonyl)-L-alaninate

Base Information

Chemical Name:tert-butyl 3-{[((5R)-3-{4-[amino(imino)methyl]phenyl}-4,5-dihydro-5-isoxazolyl)acetyl]amino}-N-((3R)-3-{[tert-butyl(dimethyl)silyl]oxy}butoxycarbonyl)-L-alaninate
CAS No.:752235-86-2
Molecular Formula:C₃₀H₄₉N₅O₇Si
Molecular Weight:619.834
Hs Code.:

tert-butyl 3-{[((5R)-3-{4-[amino(imino)methyl]phenyl}-4,5-dihydro-5-isoxazolyl)acetyl]amino}-N-((3R)-3-{[tert-butyl(dimethyl)silyl]oxy}butoxycarbonyl)-L-alaninate

Synonyms:tert-butyl 3-{[((5R)-3-{4-[amino(imino)methyl]phenyl}-4,5-dihydro-5-isoxazolyl)acetyl]amino}-N-((3R)-3-{[tert-butyl(dimethyl)silyl]oxy}butoxycarbonyl)-L-alaninate

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Chemical Property of tert-butyl 3-{[((5R)-3-{4-[amino(imino)methyl]phenyl}-4,5-dihydro-5-isoxazolyl)acetyl]amino}-N-((3R)-3-{[tert-butyl(dimethyl)silyl]oxy}butoxycarbonyl)-L-alaninate

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Technology Process of tert-butyl 3-{[((5R)-3-{4-[amino(imino)methyl]phenyl}-4,5-dihydro-5-isoxazolyl)acetyl]amino}-N-((3R)-3-{[tert-butyl(dimethyl)silyl]oxy}butoxycarbonyl)-L-alaninate

There total 9 articles about tert-butyl 3-{[((5R)-3-{4-[amino(imino)methyl]phenyl}-4,5-dihydro-5-isoxazolyl)acetyl]amino}-N-((3R)-3-{[tert-butyl(dimethyl)silyl]oxy}butoxycarbonyl)-L-alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: tert-butyl 3-{[((5R)-3-{4-[(Z)-[(acetyloxy)imino](amino)methyl]phenyl}-4,5-dihydro-5-isoxazolyl)acetyl]amino}-N-((3R)-3-{[tert-butyl(dimethyl)silyl]oxy}butoxycarbonyl)-L-alaninate

: 752235-86-2
tert-butyl 3-{[((5R)-3-{4-[amino(imino)methyl]phenyl}-4,5-dihydro-5-isoxazolyl)acetyl]amino}-N-((3R)-3-{[tert-butyl(dimethyl)silyl]oxy}butoxycarbonyl)-L-alaninate

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 1h; under 1034.3 Torr;
DOI:10.3987/COM-04-10087

Reference yield:

: 77215-55-5
tert-butyl 2-N-carbobenzoxy-(S)-2,3-diaminopropionate

: 752235-86-2
tert-butyl 3-{[((5R)-3-{4-[amino(imino)methyl]phenyl}-4,5-dihydro-5-isoxazolyl)acetyl]amino}-N-((3R)-3-{[tert-butyl(dimethyl)silyl]oxy}butoxycarbonyl)-L-alaninate

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / TBTU; Et₃N / dimethylformamide / 5 h / 20 °C

2: 55 percent / 1,4-cyclohexadiene / Pd(OH)2 / methanol / 6 h / Heating

3: 74 percent / Et₃N / tetrahydrofuran / 1.5 h / 20 °C

4: 93 percent / NH₂OH*HCl; Et₃N / methanol / 1 h / Heating

5: 72 percent / pyridine / CH₂Cl₂ / 1.5 h

6: 100 percent / H₂ / Pd/C / methanol / 1 h / 20 °C / 1034.3 Torr

With pyridine; cyclohexa-1,4-diene; hydroxylamine hydrochloride; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.3987/COM-04-10087

Reference yield:

: 181023-08-5
(R)-2-[3-(4-cyanophenyl)-4,5-dihydroisoxazol-5-yl]acetic acid

: 752235-86-2
tert-butyl 3-{[((5R)-3-{4-[amino(imino)methyl]phenyl}-4,5-dihydro-5-isoxazolyl)acetyl]amino}-N-((3R)-3-{[tert-butyl(dimethyl)silyl]oxy}butoxycarbonyl)-L-alaninate

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / TBTU; Et₃N / dimethylformamide / 5 h / 20 °C

2: 55 percent / 1,4-cyclohexadiene / Pd(OH)2 / methanol / 6 h / Heating

3: 74 percent / Et₃N / tetrahydrofuran / 1.5 h / 20 °C

4: 93 percent / NH₂OH*HCl; Et₃N / methanol / 1 h / Heating

5: 72 percent / pyridine / CH₂Cl₂ / 1.5 h

6: 100 percent / H₂ / Pd/C / methanol / 1 h / 20 °C / 1034.3 Torr

With pyridine; cyclohexa-1,4-diene; hydroxylamine hydrochloride; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.3987/COM-04-10087