N-[1-[1-(2-amino-1-(S)-carbamoyl-ethylcarbamoyl)-2-(S)-phenyl-ethylcarbamoyl]-2-(S)-(1H-indol-3-yl)-ethyl]-succinamic acid

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Chemical Name:N-[1-[1-(2-amino-1-(S)-carbamoyl-ethylcarbamoyl)-2-(S)-phenyl-ethylcarbamoyl]-2-(S)-(1H-indol-3-yl)-ethyl]-succinamic acid
CAS No.:709666-41-1
Molecular Formula:C₂₇H₃₂N₆O₆
Molecular Weight:536.588
Hs Code.:

Synonyms:N-[1-[1-(2-amino-1-(S)-carbamoyl-ethylcarbamoyl)-2-(S)-phenyl-ethylcarbamoyl]-2-(S)-(1H-indol-3-yl)-ethyl]-succinamic acid

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Chemical Property of N-[1-[1-(2-amino-1-(S)-carbamoyl-ethylcarbamoyl)-2-(S)-phenyl-ethylcarbamoyl]-2-(S)-(1H-indol-3-yl)-ethyl]-succinamic acid

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Technology Process of N-[1-[1-(2-amino-1-(S)-carbamoyl-ethylcarbamoyl)-2-(S)-phenyl-ethylcarbamoyl]-2-(S)-(1H-indol-3-yl)-ethyl]-succinamic acid

There total 4 articles about N-[1-[1-(2-amino-1-(S)-carbamoyl-ethylcarbamoyl)-2-(S)-phenyl-ethylcarbamoyl]-2-(S)-(1H-indol-3-yl)-ethyl]-succinamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 709666-38-6
N-[1-[1-(2-benzyloxycarbonylamino-1-(S)-carbamoyl-ethylcarbamoyl)-2-(S)-phenyl-ethylcarbamoyl]-2-(S)-(1H-indol-3-yl)-ethyl]-succinamic acid

: 709666-41-1
N-[1-[1-(2-amino-1-(S)-carbamoyl-ethylcarbamoyl)-2-(S)-phenyl-ethylcarbamoyl]-2-(S)-(1H-indol-3-yl)-ethyl]-succinamic acid

Guidance literature:: With hydrogen; 10percent Pd/C; In ethanol; for 4h;
DOI:10.1021/jm011127h

Reference yield:

: 34337-45-6
Boc-Trp-Phe-OH

: 709666-41-1
N-[1-[1-(2-amino-1-(S)-carbamoyl-ethylcarbamoyl)-2-(S)-phenyl-ethylcarbamoyl]-2-(S)-(1H-indol-3-yl)-ethyl]-succinamic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 53 percent / PyBOP; TEA / CH₂Cl₂

2: 97 percent / TFA / CH₂Cl₂ / 1.5 h

3: 82 percent / DIPEA / dimethylformamide / 2 h

4: 82 percent / H₂ / 10percent Pd/C / ethanol / 4 h

With TEA; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 10percent Pd/C; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm011127h

Reference yield:

: 709665-35-0
H-Trp-Phe-Dpr(Z)-NH₂

: 709666-41-1
N-[1-[1-(2-amino-1-(S)-carbamoyl-ethylcarbamoyl)-2-(S)-phenyl-ethylcarbamoyl]-2-(S)-(1H-indol-3-yl)-ethyl]-succinamic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / DIPEA / dimethylformamide / 2 h

2: 82 percent / H₂ / 10percent Pd/C / ethanol / 4 h

With hydrogen; N-ethyl-N,N-diisopropylamine; 10percent Pd/C; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm011127h