3-(methoxycarbonyl-(4-(4-morpholin-4-ylmethylphenylethynyl)benzoylamino)methyl)pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Base Information

Chemical Name:3-(methoxycarbonyl-(4-(4-morpholin-4-ylmethylphenylethynyl)benzoylamino)methyl)pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester
CAS No.:1093191-38-8
Molecular Formula:C₄₂H₄₁N₃O₆
Molecular Weight:683.804
Hs Code.:

3-(methoxycarbonyl-(4-(4-morpholin-4-ylmethylphenylethynyl)benzoylamino)methyl)pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Synonyms:3-(methoxycarbonyl-(4-(4-morpholin-4-ylmethylphenylethynyl)benzoylamino)methyl)pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

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Chemical Property of 3-(methoxycarbonyl-(4-(4-morpholin-4-ylmethylphenylethynyl)benzoylamino)methyl)pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

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Technology Process of 3-(methoxycarbonyl-(4-(4-morpholin-4-ylmethylphenylethynyl)benzoylamino)methyl)pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

There total 7 articles about 3-(methoxycarbonyl-(4-(4-morpholin-4-ylmethylphenylethynyl)benzoylamino)methyl)pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1093191-34-4
4-(4-morpholin-4-ylmethylphenylethynyl)benzoic acid hydrochloride

: 1093191-37-7
3-(amino(methoxycarbonyl)methyl)pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester hydrochloride

: 1093191-38-8
3-(methoxycarbonyl-(4-(4-morpholin-4-ylmethylphenylethynyl)benzoylamino)methyl)pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: 4-(4-morpholin-4-ylmethylphenylethynyl)benzoic acid hydrochloride; With O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

3-(amino(methoxycarbonyl)methyl)pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 3032-92-6
4-cyanophenylacetylene

: 1093191-38-8
3-(methoxycarbonyl-(4-(4-morpholin-4-ylmethylphenylethynyl)benzoylamino)methyl)pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 20 °C

2.1: sodium tris(acetoxy)borohydride / chloroform / 4 h / 20 °C

3.1: lithium hydroxide; water / 1,4-dioxane / 0.75 h / 130 °C / Microwave irradiation

3.2: pH ~ 3

4.1: O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 20 °C

With lithium hydroxide; copper(l) iodide; O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; water; sodium tris(acetoxy)borohydride; triethylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 15164-44-0
p-(iodophenyl)carboxaldehyde

: 1093191-38-8
3-(methoxycarbonyl-(4-(4-morpholin-4-ylmethylphenylethynyl)benzoylamino)methyl)pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 20 °C

2.1: sodium tris(acetoxy)borohydride / chloroform / 4 h / 20 °C

3.1: lithium hydroxide; water / 1,4-dioxane / 0.75 h / 130 °C / Microwave irradiation

3.2: pH ~ 3

4.1: O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 20 °C

With lithium hydroxide; copper(l) iodide; O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; water; sodium tris(acetoxy)borohydride; triethylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; chloroform; N,N-dimethyl-formamide;