(S)-tert-butyl-2-((S)-1-cyano-2-(4-iodophenyl)ethylcarbamoyl)piperidine-1-carboxylate

Base Information

Chemical Name:(S)-tert-butyl-2-((S)-1-cyano-2-(4-iodophenyl)ethylcarbamoyl)piperidine-1-carboxylate
CAS No.:1161498-11-8
Molecular Formula:C₂₀H₂₆IN₃O₃
Molecular Weight:483.349
Hs Code.:

Synonyms:(S)-tert-butyl-2-((S)-1-cyano-2-(4-iodophenyl)ethylcarbamoyl)piperidine-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-tert-butyl-2-((S)-1-cyano-2-(4-iodophenyl)ethylcarbamoyl)piperidine-1-carboxylate

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Technology Process of (S)-tert-butyl-2-((S)-1-cyano-2-(4-iodophenyl)ethylcarbamoyl)piperidine-1-carboxylate

There total 1 articles about (S)-tert-butyl-2-((S)-1-cyano-2-(4-iodophenyl)ethylcarbamoyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1161498-12-9
(S)-tert-butyl 2-((S)-1-amino-3-(4-iodophenyl)-1-oxopropan-2-yl carbamoyl)piperidine-1-carboxylate

: 1161498-11-8
(S)-tert-butyl-2-((S)-1-cyano-2-(4-iodophenyl)ethylcarbamoyl)piperidine-1-carboxylate

Guidance literature:: With methyl chlorosulfonylcarbamate; triethylamine; In benzene; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm401705g

Reference yield: 86.0%

: 1161498-11-8
(S)-tert-butyl-2-((S)-1-cyano-2-(4-iodophenyl)ethylcarbamoyl)piperidine-1-carboxylate

: 126747-14-6
4-cyanophenylboronic acid

: (S)-tert-butyl-2-((S)-1-cyano-2-(4'-cyanobiphenyl-4-yl)ethylcarbamoyl)piperidine-1-carboxylate

Guidance literature:: (S)-tert-butyl-2-((S)-1-cyano-2-(4-iodophenyl)ethylcarbamoyl)piperidine-1-carboxylate; 4-cyanophenylboronic acid; With bis[1,2-bis(diphenylphosphino)ethane]palladium⁽⁰⁾; In 1,4-dioxane; for 0.25h; Inert atmosphere;

With potassium carbonate; In 1,4-dioxane; water; at 75 ℃; Inert atmosphere;
DOI:10.1021/jm401705g

Reference yield:

: 1161498-11-8
(S)-tert-butyl-2-((S)-1-cyano-2-(4-iodophenyl)ethylcarbamoyl)piperidine-1-carboxylate

: C₂₈H₃₆N₄O₅S

Guidance literature:: (S)-tert-butyl-2-((S)-1-cyano-2-(4-iodophenyl)ethylcarbamoyl)piperidine-1-carboxylate; bis[1,2-bis(diphenylphosphino)ethane]palladium⁽⁰⁾; In 1,4-dioxane; at 20 ℃; for 0.166667h;

With potassium carbonate; In 1,4-dioxane; water; at 75 ℃;