(2E,4E)-2-benzoyl-5-phenylpenta-2,4-dienenitrile

Base Information

Chemical Name:(2E,4E)-2-benzoyl-5-phenylpenta-2,4-dienenitrile
CAS No.:1261378-66-8
Molecular Formula:C₁₈H₁₃NO
Molecular Weight:259.307
Hs Code.:

Synonyms:(2E,4E)-2-benzoyl-5-phenylpenta-2,4-dienenitrile

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Chemical Property of (2E,4E)-2-benzoyl-5-phenylpenta-2,4-dienenitrile

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Technology Process of (2E,4E)-2-benzoyl-5-phenylpenta-2,4-dienenitrile

There total 2 articles about (2E,4E)-2-benzoyl-5-phenylpenta-2,4-dienenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: (E)-2-benzoyl-5-phenylpent-4-enenitrile

: 1261378-66-8
(2E,4E)-2-benzoyl-5-phenylpenta-2,4-dienenitrile

Guidance literature:: With dichloro bis(acetonitrile) palladium(II); toluene-4-sulfonic acid; p-benzoquinone; In tetrahydrofuran; at 80 ℃; for 8h;
DOI:10.1039/c7ob00912g

Reference yield:

: 614-16-4
Benzoylacetonitrile

: 4392-24-9
Cinnamyl bromide

: 1261378-66-8
(2E,4E)-2-benzoyl-5-phenylpenta-2,4-dienenitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C

1.2: 20 °C

2.1: dichloro bis(acetonitrile) palladium(II); p-benzoquinone; toluene-4-sulfonic acid / tetrahydrofuran / 8 h / 80 °C

With dichloro bis(acetonitrile) palladium(II); sodium hydride; toluene-4-sulfonic acid; p-benzoquinone; In tetrahydrofuran;
DOI:10.1039/c7ob00912g

Reference yield: 78.0%

: 1261378-66-8
(2E,4E)-2-benzoyl-5-phenylpenta-2,4-dienenitrile

: 1261378-90-8
(2R,3S)-2-(4-methoxybenzoyl)-3E-styryloxirane-2-carbonitrile

Guidance literature:: With tert.-butylhydroperoxide; bis(3,5-dimethylphenyl)-(S)-pyrrolidin-2-ylmethanol; In decane; m-xylene; at -20 ℃; optical yield given as %ee; enantioselective reaction;
DOI:10.1021/jo102020a