N⁴-di(tert-butyl)(isobutyl)silyl-5'-(4,4'-dimethoxytrityl)-2'-deoxycytidine

Base Information

Chemical Name:N⁴-di(tert-butyl)(isobutyl)silyl-5'-(4,4'-dimethoxytrityl)-2'-deoxycytidine
CAS No.:1430099-58-3
Molecular Formula:C₄₂H₅₇N₃O₆Si
Molecular Weight:728.017
Hs Code.:

N<SUP>4</SUP>-di(tert-butyl)(isobutyl)silyl-5'-(4,4'-dimethoxytrityl)-2'-deoxycytidine

Synonyms:N⁴-di(tert-butyl)(isobutyl)silyl-5'-(4,4'-dimethoxytrityl)-2'-deoxycytidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N⁴-di(tert-butyl)(isobutyl)silyl-5'-(4,4'-dimethoxytrityl)-2'-deoxycytidine

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Technology Process of N⁴-di(tert-butyl)(isobutyl)silyl-5'-(4,4'-dimethoxytrityl)-2'-deoxycytidine

There total 4 articles about N⁴-di(tert-butyl)(isobutyl)silyl-5'-(4,4'-dimethoxytrityl)-2'-deoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: C₂₁H₃₉N₃O₄Si

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1430099-58-3
N⁴-di(tert-butyl)(isobutyl)silyl-5'-(4,4'-dimethoxytrityl)-2'-deoxycytidine

Guidance literature:: With pyridine; at 20 ℃; Reagent/catalyst;

Reference yield:

: 1314639-86-5
di-tert-butylisobutylsilyl trifluoromethanesulfonate

: 1430099-58-3
N⁴-di(tert-butyl)(isobutyl)silyl-5'-(4,4'-dimethoxytrityl)-2'-deoxycytidine

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; triethylamine / 1,4-dioxane / 2 h / 50 °C / Inert atmosphere

2: ammonia; methanol

3: N-ethyl-N,N-diisopropylamine; pyridine / 20 °C

With pyridine; methanol; dmap; ammonia; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane;
DOI:10.1021/ja400898s

Reference yield:

: 65919-98-4
3',5'-di-O-acetyl-2'-deoxycytidine

: 1430099-58-3
N⁴-di(tert-butyl)(isobutyl)silyl-5'-(4,4'-dimethoxytrityl)-2'-deoxycytidine

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; triethylamine / 1,4-dioxane / 2 h / 50 °C / Inert atmosphere

2: ammonia; methanol

3: N-ethyl-N,N-diisopropylamine; pyridine / 20 °C

With pyridine; methanol; dmap; ammonia; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane;
DOI:10.1021/ja400898s