Benzamide, 4-(((((((2S)-4-((3,4-dichlorophenyl)methyl)-2-morpholinyl)methyl)amino)carbonyl)amino)methyl)-

Base Information

• Chemical Name: Benzamide, 4-(((((((2S)-4-((3,4-dichlorophenyl)methyl)-2-morpholinyl)methyl)amino)carbonyl)amino)methyl)-
• CAS No.: 408303-43-5
• Molecular Formula: C₂₁H₂₄Cl₂N₄O₃
• Molecular Weight: 451.353
• UNII: Z6213K1TPE
• Wikidata: Q27295049
• ChEMBL ID: CHEMBL5088752
• Mol file: 408303-43-5.mol

Synonyms:GW 766994;408303-43-5;GW-994;Z6213K1TPE;GW-766994;UNII-Z6213K1TPE;Benzamide, 4-(((((((2S)-4-((3,4-dichlorophenyl)methyl)-2-morpholinyl)methyl)amino)carbonyl)amino)methyl)-;4-[[[[[[(2S)-4-[(3,4-dichlorophenyl)methyl]-2-morpholinyl]methyl]amino]carbonyl]amino]methyl]-benzamide;SCHEMBL1191539;CHEMBL5088752;GPLUUMAKBFSDIE-KRWDZBQOSA-N;GLXC-25185;GW 994;AKOS040733344;MS-28194;HY-107051;CS-0027219;Q27295049;4-({[({[(2S)-4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}amino)carbonyl]amino}-methyl)benzamide;4-({[({[(2S)-4-(3,4-Dichlorobenzyl)morpholin-2-yl]methyl}amino)carbonyl]amino}methyl)benzamide;4-[[[(2S)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylcarbamoylamino]methyl]benzamide

Chemical Property of Benzamide, 4-(((((((2S)-4-((3,4-dichlorophenyl)methyl)-2-morpholinyl)methyl)amino)carbonyl)amino)methyl)-

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 450.1225460
• Heavy Atom Count: 30
• Complexity: 575

Purity/Quality:

97% ^*data from raw suppliers

GW766994 99.53% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1COC(CN1CC2=CC(=C(C=C2)Cl)Cl)CNC(=O)NCC3=CC=C(C=C3)C(=O)N
• Isomeric SMILES: C1CO[C@H](CN1CC2=CC(=C(C=C2)Cl)Cl)CNC(=O)NCC3=CC=C(C=C3)C(=O)N
• Description: GW 766994 is an antagonist of chemokine (C-C motif) receptor 3 (CCR3) with a Ki value of 13.8 nM in an assay of eosinophil chemotaxis induced by chemokine (C-C motif) ligand 11 (CCL11). It decreases CCL11-induced cyclin-dependent kinase 5 (Cdk5) and tau phosphorylation and production of amyloid β (1-42) (Aβ42) in isolated mouse hippocampal neurons when used at a concentration of 10 μM.

Technology Process of Benzamide, 4-(((((((2S)-4-((3,4-dichlorophenyl)methyl)-2-morpholinyl)methyl)amino)carbonyl)amino)methyl)-

There total 2 articles about Benzamide, 4-(((((((2S)-4-((3,4-dichlorophenyl)methyl)-2-morpholinyl)methyl)amino)carbonyl)amino)methyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S)-2-aminomethyl-4-(3,4-dichlorobenzyl)morpholine (407640-11-3) + 4-(aminomethyl)benzamide (369-53-9) → GW766994 (408303-43-5)

Guidance literature:

(2S)-2-aminomethyl-4-(3,4-dichlorobenzyl)morpholine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 5 - 18 ℃; for 0.416667h;

4-(aminomethyl)benzamide; In tetrahydrofuran; at 57 - 63 ℃; for 1.25h;

Reference yield:

→ GW766994 (408303-43-5)

Guidance literature:

Reference yield: 19.5%

GW766994 (408303-43-5) → (S)-4-((3-((4-(3,4-dichlorobenzyl)morpholin-2-yl)methyl)ureido)methyl)benzoic acid (408304-11-0)

Guidance literature:

With water; lithium hydroxide; In 1,4-dioxane; methanol; for 70h;

upstream raw materials:

(2S)-2-aminomethyl-4-(3,4-dichlorobenzyl)morpholine

4-(aminomethyl)benzamide

Downstream raw materials:

(S)-4-((3-((4-(3,4-dichlorobenzyl)morpholin-2-yl)methyl)ureido)methyl)benzoic acid