1-(3-(4-fluorophenyl)-N-methylacrylamido)-6-methylhept-3-yn-2-yl acetate

Base Information

Chemical Name:1-(3-(4-fluorophenyl)-N-methylacrylamido)-6-methylhept-3-yn-2-yl acetate
CAS No.:1449377-84-7
Molecular Formula:C₂₀H₂₄FNO₃
Molecular Weight:345.414
Hs Code.:

Synonyms:1-(3-(4-fluorophenyl)-N-methylacrylamido)-6-methylhept-3-yn-2-yl acetate

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Chemical Property of 1-(3-(4-fluorophenyl)-N-methylacrylamido)-6-methylhept-3-yn-2-yl acetate

Chemical Property:

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Technology Process of 1-(3-(4-fluorophenyl)-N-methylacrylamido)-6-methylhept-3-yn-2-yl acetate

There total 4 articles about 1-(3-(4-fluorophenyl)-N-methylacrylamido)-6-methylhept-3-yn-2-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13565-08-7
(E)-3-(4-fluorophenyl)acryloyl chloride

: 1449377-84-7
1-(3-(4-fluorophenyl)-N-methylacrylamido)-6-methylhept-3-yn-2-yl acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 - 20 °C

2.1: pyridinium p-toluenesulfonate / acetone; water / 48 h / Reflux

3.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.2: 6 h / -78 - 0 °C

4.1: triethylamine; dmap / dichloromethane / 2 h

With dmap; n-butyllithium; pyridinium p-toluenesulfonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; acetone;
DOI:10.1002/anie.201207287

Reference yield:

: 1449378-07-7
3-(4-fluorophenyl)-N-methyl-N-(2-oxoethyl)acrylamide

: 1449377-84-7
1-(3-(4-fluorophenyl)-N-methylacrylamido)-6-methylhept-3-yn-2-yl acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 6 h / -78 - 0 °C

2.1: triethylamine; dmap / dichloromethane / 2 h

With dmap; n-butyllithium; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.201207287

Reference yield:

: C₁₄H₁₈FNO₃

: 1449377-84-7
1-(3-(4-fluorophenyl)-N-methylacrylamido)-6-methylhept-3-yn-2-yl acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridinium p-toluenesulfonate / acetone; water / 48 h / Reflux

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 6 h / -78 - 0 °C

3.1: triethylamine; dmap / dichloromethane / 2 h

With dmap; n-butyllithium; pyridinium p-toluenesulfonate; triethylamine; In tetrahydrofuran; dichloromethane; water; acetone;
DOI:10.1002/anie.201207287