3'-O-acetyl-5'-O-benzyl-N⁶-dimethoxytrityl-2'-O-p-methoxybenzyladenosine

Base Information

Chemical Name:3'-O-acetyl-5'-O-benzyl-N⁶-dimethoxytrityl-2'-O-p-methoxybenzyladenosine
CAS No.:286365-21-7
Molecular Formula:C₄₈H₄₇N₅O₈
Molecular Weight:821.93
Hs Code.:

3'-O-acetyl-5'-O-benzyl-N<sup>6</sup>-dimethoxytrityl-2'-O-p-methoxybenzyladenosine

Synonyms:3'-O-acetyl-5'-O-benzyl-N⁶-dimethoxytrityl-2'-O-p-methoxybenzyladenosine

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Chemical Property of 3'-O-acetyl-5'-O-benzyl-N⁶-dimethoxytrityl-2'-O-p-methoxybenzyladenosine

Chemical Property:

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Technology Process of 3'-O-acetyl-5'-O-benzyl-N⁶-dimethoxytrityl-2'-O-p-methoxybenzyladenosine

There total 9 articles about 3'-O-acetyl-5'-O-benzyl-N⁶-dimethoxytrityl-2'-O-p-methoxybenzyladenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 108-24-7
acetic anhydride

: 286365-19-3
exo/endo-5'-O-benzyl-N⁶-dimethoxytrityl-2',3'-O-p-methoxybenzylideneadenosine

: 286365-21-7
3'-O-acetyl-5'-O-benzyl-N⁶-dimethoxytrityl-2'-O-p-methoxybenzyladenosine

: 2'-O-acetyl-5'-O-benzyl-N⁶-dimethoxytrityl-3'-O-p-methoxybenzyladenosine

Guidance literature:: exo/endo-5'-O-benzyl-N⁶-dimethoxytrityl-2',3'-O-p-methoxybenzylideneadenosine; With diisobutylaluminium hydride; In dichloromethane; at -78 ℃;

acetic anhydride; With pyridine;
DOI:10.1016/S0957-4166(99)00491-7

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 286365-21-7
3'-O-acetyl-5'-O-benzyl-N⁶-dimethoxytrityl-2'-O-p-methoxybenzyladenosine

Guidance literature:: Multi-step reaction with 4 steps

2.1: conc. aq. NH₄OH

3.1: 95 percent / KOH / benzene; dioxane / Heating

4.1: DIBAL-H / CH₂Cl₂ / -78 °C

4.2: 55 percent / pyridine

With potassium hydroxide; ammonium hydroxide; diisobutylaluminium hydride; In 1,4-dioxane; dichloromethane; benzene; 1.1: Tritylation / 2.1: Desilylation / 3.1: benzylation / 4.1: Ring cleavage / 4.2: Acetylation;
DOI:10.1016/S0957-4166(99)00491-7

Reference yield:

: 100-44-7
benzyl chloride

: 286365-21-7
3'-O-acetyl-5'-O-benzyl-N⁶-dimethoxytrityl-2'-O-p-methoxybenzyladenosine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 95 percent / KOH / benzene; dioxane / Heating

2.1: DIBAL-H / CH₂Cl₂ / -78 °C

2.2: 55 percent / pyridine

With potassium hydroxide; diisobutylaluminium hydride; In 1,4-dioxane; dichloromethane; benzene; 1.1: benzylation / 2.1: Ring cleavage / 2.2: Acetylation;
DOI:10.1016/S0957-4166(99)00491-7