(S,E)-ethyl 3-(3-fluoro-2-((1-(4-methoxyphenyl)ethylimino)methyl)phenyl)propanoate

Base Information

Chemical Name:(S,E)-ethyl 3-(3-fluoro-2-((1-(4-methoxyphenyl)ethylimino)methyl)phenyl)propanoate
CAS No.:1346004-15-6
Molecular Formula:C₂₁H₂₄FNO₃
Molecular Weight:357.425
Hs Code.:

Synonyms:(S,E)-ethyl 3-(3-fluoro-2-((1-(4-methoxyphenyl)ethylimino)methyl)phenyl)propanoate

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Chemical Property of (S,E)-ethyl 3-(3-fluoro-2-((1-(4-methoxyphenyl)ethylimino)methyl)phenyl)propanoate

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Technology Process of (S,E)-ethyl 3-(3-fluoro-2-((1-(4-methoxyphenyl)ethylimino)methyl)phenyl)propanoate

There total 4 articles about (S,E)-ethyl 3-(3-fluoro-2-((1-(4-methoxyphenyl)ethylimino)methyl)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1346004-36-1
ethyl 3-(2-(1,3-dioxan-2-yl)-3-fluorophenyl)propanoate

: 1346004-15-6
(S,E)-ethyl 3-(3-fluoro-2-((1-(4-methoxyphenyl)ethylimino)methyl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / water / 12 h / 20 °C / Inert atmosphere

2.1: magnesium sulfate / dichloromethane / 0.08 h / Inert atmosphere

2.2: 5 h / 20 °C / Inert atmosphere

With magnesium sulfate; acetic acid; In dichloromethane; water;
DOI:10.1021/ol202750u

Reference yield:

: 1346004-26-9
2-(2-bromo-6-fluorophenyl)-1,3-dioxane

: 1346004-15-6
(S,E)-ethyl 3-(3-fluoro-2-((1-(4-methoxyphenyl)ethylimino)methyl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium diacetate; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine / acetonitrile / 24 h / Reflux; Inert atmosphere

2.1: cobalt(II) chloride hexahydrate / ethanol / 0.5 h / 0 °C / Inert atmosphere

2.2: 72 h / 20 °C / Inert atmosphere

3.1: acetic acid / water / 12 h / 20 °C / Inert atmosphere

4.1: magnesium sulfate / dichloromethane / 0.08 h / Inert atmosphere

4.2: 5 h / 20 °C / Inert atmosphere

With cobalt(II) chloride hexahydrate; palladium diacetate; magnesium sulfate; acetic acid; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; In ethanol; dichloromethane; water; acetonitrile; 1.1: Heck reaction;
DOI:10.1021/ol202750u

Reference yield:

: 1346004-30-5
(E)-ethyl 3-(2-(1,3-dioxan-2-yl)-3-fluorophenyl)acrylate

: 1346004-15-6
(S,E)-ethyl 3-(3-fluoro-2-((1-(4-methoxyphenyl)ethylimino)methyl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: cobalt(II) chloride hexahydrate / ethanol / 0.5 h / 0 °C / Inert atmosphere

1.2: 72 h / 20 °C / Inert atmosphere

2.1: acetic acid / water / 12 h / 20 °C / Inert atmosphere

3.1: magnesium sulfate / dichloromethane / 0.08 h / Inert atmosphere

3.2: 5 h / 20 °C / Inert atmosphere

With cobalt(II) chloride hexahydrate; magnesium sulfate; acetic acid; In ethanol; dichloromethane; water;
DOI:10.1021/ol202750u