ethyl N-[2,6-bis(2-fluorophenyl)-4-phenylphenyl](2,6-dimethyl-4-phenylphenyl)methylcarbamate

Base Information

Chemical Name:ethyl N-[2,6-bis(2-fluorophenyl)-4-phenylphenyl](2,6-dimethyl-4-phenylphenyl)methylcarbamate
CAS No.:787576-80-1
Molecular Formula:C₄₂H₃₅F₂NO₂
Molecular Weight:623.742
Hs Code.:

Synonyms:ethyl N-[2,6-bis(2-fluorophenyl)-4-phenylphenyl](2,6-dimethyl-4-phenylphenyl)methylcarbamate

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Chemical Property of ethyl N-[2,6-bis(2-fluorophenyl)-4-phenylphenyl](2,6-dimethyl-4-phenylphenyl)methylcarbamate

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Technology Process of ethyl N-[2,6-bis(2-fluorophenyl)-4-phenylphenyl](2,6-dimethyl-4-phenylphenyl)methylcarbamate

There total 6 articles about ethyl N-[2,6-bis(2-fluorophenyl)-4-phenylphenyl](2,6-dimethyl-4-phenylphenyl)methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1993-03-9
o-fluorophenylboronic acid

: 787576-86-7
ethyl N-(2,6-dibromo-4-phenylphenyl)(2,6-dimethyl-4-phenylphenyl)methylcarbamate

: 787576-80-1
ethyl N-[2,6-bis(2-fluorophenyl)-4-phenylphenyl](2,6-dimethyl-4-phenylphenyl)methylcarbamate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; for 24h; Heating;
DOI:10.1021/ja047738r

Reference yield:

: 17057-88-4
3,5-dimethylbiphenyl

: 787576-80-1
ethyl N-[2,6-bis(2-fluorophenyl)-4-phenylphenyl](2,6-dimethyl-4-phenylphenyl)methylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 97 percent / Br₂ / CCl₄ / 20 °C

2.1: n-BuLi / diethyl ether; hexane / 3 h / -78 °C

2.2: 79 percent / diethyl ether; hexane / -78 - 20 °C

3.1: n-BuLi / diethyl ether; hexane / 5 h / -78 °C

3.2: 85 percent / diethyl ether; hexane / -78 - 20 °C

4.1: SOCl₂ / 24 h / 35 °C

5.1: 63 percent / AgBF₄ / dioxane / 24 h / 100 °C

6.1: 79 percent / Pd(PPh₃)4; aq. Na₂CO₃ / 1,2-dimethoxy-ethane / 24 h / Heating

With silver tetrafluoroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; thionyl chloride; bromine; sodium carbonate; In 1,4-dioxane; tetrachloromethane; 1,2-dimethoxyethane; diethyl ether; hexane; 6.1: Suzuki coupling;
DOI:10.1021/ja047738r

Reference yield:

: 787576-84-5
3,5-dimethyl-[1,1'-biphenyl]-4-carbaldehyde

: 787576-80-1
ethyl N-[2,6-bis(2-fluorophenyl)-4-phenylphenyl](2,6-dimethyl-4-phenylphenyl)methylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / diethyl ether; hexane / 5 h / -78 °C

1.2: 85 percent / diethyl ether; hexane / -78 - 20 °C

2.1: SOCl₂ / 24 h / 35 °C

3.1: 63 percent / AgBF₄ / dioxane / 24 h / 100 °C

4.1: 79 percent / Pd(PPh₃)4; aq. Na₂CO₃ / 1,2-dimethoxy-ethane / 24 h / Heating

With silver tetrafluoroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; thionyl chloride; sodium carbonate; In 1,4-dioxane; 1,2-dimethoxyethane; diethyl ether; hexane; 4.1: Suzuki coupling;
DOI:10.1021/ja047738r