ethyl 2,5-difluoro-3-methoxy-4-[7-(S)-[1-(S)-phenylethyl]amino-5-azaspiro[2.4]hept-5-yl]benzoate

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Chemical Name:ethyl 2,5-difluoro-3-methoxy-4-[7-(S)-[1-(S)-phenylethyl]amino-5-azaspiro[2.4]hept-5-yl]benzoate
CAS No.:627532-54-1
Molecular Formula:C₂₄H₂₈F₂N₂O₃
Molecular Weight:430.495
Hs Code.:

Synonyms:ethyl 2,5-difluoro-3-methoxy-4-[7-(S)-[1-(S)-phenylethyl]amino-5-azaspiro[2.4]hept-5-yl]benzoate

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Chemical Property of ethyl 2,5-difluoro-3-methoxy-4-[7-(S)-[1-(S)-phenylethyl]amino-5-azaspiro[2.4]hept-5-yl]benzoate

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Technology Process of ethyl 2,5-difluoro-3-methoxy-4-[7-(S)-[1-(S)-phenylethyl]amino-5-azaspiro[2.4]hept-5-yl]benzoate

There total 1 articles about ethyl 2,5-difluoro-3-methoxy-4-[7-(S)-[1-(S)-phenylethyl]amino-5-azaspiro[2.4]hept-5-yl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 351354-45-5
ethyl 2,4,5-trifluoro-3-methoxybenzoate

: 442513-54-4
7-(S)-[1-(S)-phenylethyl]amino-5-azaspiro[2.4]heptane oxalic acid salt

: 627532-54-1
ethyl 2,5-difluoro-3-methoxy-4-[7-(S)-[1-(S)-phenylethyl]amino-5-azaspiro[2.4]hept-5-yl]benzoate

Guidance literature:: With potassium carbonate; In acetonitrile; for 6h; Heating / reflux;

Reference yield: 85.0%

: 627532-54-1
ethyl 2,5-difluoro-3-methoxy-4-[7-(S)-[1-(S)-phenylethyl]amino-5-azaspiro[2.4]hept-5-yl]benzoate

: 627532-56-3
2,5-difluoro-3-methoxy-4-[7-(S)-[1-(S)-phenylethyl]amino-5-azaspiro[2.4]hept-5-yl]benzoic acid

Guidance literature:: ethyl 2,5-difluoro-3-methoxy-4-[7-(S)-[1-(S)-phenylethyl]amino-5-azaspiro[2.4]hept-5-yl]benzoate; With potassium hydroxide; water; In ethanol; at 80 ℃; for 1.5h;

With hydrogenchloride; In ethanol; at 0 ℃;