5'-O-(4,4'-dimethoxytrityl)-4'-C-(4,4'-dimethoxytrityloxymethyl)thymidine

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-4'-C-(4,4'-dimethoxytrityloxymethyl)thymidine
• CAS No.: 172360-64-4
• Molecular Formula: C₅₃H₅₂N₂O₁₀
• Molecular Weight: 877.003
• Mol file: 172360-64-4.mol

Synonyms:5'-O-(4,4'-dimethoxytrityl)-4'-C-(4,4'-dimethoxytrityloxymethyl)thymidine

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-4'-C-(4,4'-dimethoxytrityloxymethyl)thymidine

Chemical Property:

Purity/Quality:

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-4'-C-(4,4'-dimethoxytrityloxymethyl)thymidine

There total 1 articles about 5'-O-(4,4'-dimethoxytrityl)-4'-C-(4,4'-dimethoxytrityloxymethyl)thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-4'-C-(4,4'-dimethoxytrityloxymethyl)thymidine → 5'-O-(4,4'-dimethoxytrityl)-4'-C-(4,4'-dimethoxytrityloxymethyl)thymidine (172360-64-4)

Guidance literature:

With potassium fluoride; 18-crown-6 ether; In N,N-dimethyl-formamide; for 48h; Ambient temperature;

DOI:10.1016/0040-4020(95)00606-9

Reference yield: 89.0%

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) + 5'-O-(4,4'-dimethoxytrityl)-4'-C-(4,4'-dimethoxytrityloxymethyl)thymidine (172360-64-4) → 3'-O-(2-cyanoethoxy(diisopropylaminophosphino))-5'-O-(4,4'-dimethoxytrityl)-4'-C-(4,4'-dimethoxytrityloxymethyl)thimidine

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1016/0040-4020(95)00606-9

Reference yield: 68.0%

acetic anhydride (108-24-7) + 5'-O-(4,4'-dimethoxytrityl)-4'-C-(4,4'-dimethoxytrityloxymethyl)thymidine (172360-64-4) → 3'-O-acetyl-5'-O-(4,4'-dimethoxytrityl)-4'-C-(4,4'-dimethoxytrityloxymethyl)thymidine

Guidance literature:

With pyridine; dmap; triethylamine; for 5h; Ambient temperature;

DOI:10.1016/0040-4020(95)00606-9