(R)-2-[5-(5-chloro-2-fluorophenyl)pyridin-3-ylamino]-2-phenylacetamide

Base Information

Chemical Name:(R)-2-[5-(5-chloro-2-fluorophenyl)pyridin-3-ylamino]-2-phenylacetamide
CAS No.:1569319-69-2
Molecular Formula:C₁₉H₁₅ClFN₃O
Molecular Weight:355.799
Hs Code.:

Synonyms:(R)-2-[5-(5-chloro-2-fluorophenyl)pyridin-3-ylamino]-2-phenylacetamide

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Chemical Property of (R)-2-[5-(5-chloro-2-fluorophenyl)pyridin-3-ylamino]-2-phenylacetamide

Chemical Property:

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Technology Process of (R)-2-[5-(5-chloro-2-fluorophenyl)pyridin-3-ylamino]-2-phenylacetamide

There total 4 articles about (R)-2-[5-(5-chloro-2-fluorophenyl)pyridin-3-ylamino]-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1569320-04-2
2-(5-bromopyridin-3-ylamino)-2-phenylacetamide

: 352535-83-2
5-chloro-2-fluorophenylboronic acid

: 1569319-69-2
(R)-2-[5-(5-chloro-2-fluorophenyl)pyridin-3-ylamino]-2-phenylacetamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; at 80 ℃; for 10h; Inert atmosphere;

Reference yield:

: 1569320-03-1
((5-bromopyridin-3-yl)amino)phenylacetic acid

: 1569319-69-2
(R)-2-[5-(5-chloro-2-fluorophenyl)pyridin-3-ylamino]-2-phenylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonia; triethylamine / N,N-dimethyl-formamide; 1,4-dioxane / 0.5 h

1.2: 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 10 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; potassium carbonate; triethylamine; In 1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

: 625-92-3
3,5-dibromopyridine

: 1569319-69-2
(R)-2-[5-(5-chloro-2-fluorophenyl)pyridin-3-ylamino]-2-phenylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide; L-proline; potassium carbonate / dimethyl sulfoxide / 12 h / 90 °C / Inert atmosphere

2.1: ammonia; triethylamine / N,N-dimethyl-formamide; 1,4-dioxane / 0.5 h

2.2: 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 10 h / 80 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; potassium carbonate; triethylamine; L-proline; In 1,4-dioxane; 1,2-dimethoxyethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;