C₁₈H₂₁NO₄

Base Information

Chemical Name:C₁₈H₂₁NO₄
CAS No.:1422971-71-8
Molecular Formula:C₁₈H₂₁NO₄
Molecular Weight:315.369
Hs Code.:

C<sub>18</sub>H<sub>21</sub>NO<sub>4</sub>

Synonyms:C₁₈H₂₁NO₄

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Chemical Property of C₁₈H₂₁NO₄

Chemical Property:

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Technology Process of C₁₈H₂₁NO₄

There total 18 articles about C₁₈H₂₁NO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: C₁₉H₂₃NO₄

: 1422971-71-8
C₁₈H₂₁NO₄

Guidance literature:: With (1S)-10-camphorsulfonic acid; In tetrahydrofuran; Reflux;
DOI:10.1055/s-0032-1318114

Reference yield:

: {(1S,4S)-2-Bromo-4-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-cyclohex-2-enyl}-tert-butoxycarbonylamino-acetic acid

: 1422971-71-8
C₁₈H₂₁NO₄

Guidance literature:: Multi-step reaction with 15 steps

1: diethyl ether / 0 °C

2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; caesium carbonate / tetrahydrofuran / Reflux

3: tetrabutyl ammonium fluoride / tetrahydrofuran

4: tributylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C

5: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

6: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

7: sodium hydride / tetrahydrofuran / 0 °C

8: 2-hydroxynitrobenzene / 144 h / 130 °C / Inert atmosphere

9: sodium hydroxide / methanol; water / 80 °C

10: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

11: Dess-Martin periodane / dichloromethane

12: boron trifluoride diethyl etherate / dichloromethane / 3 h / -10 °C

13: diphenylsilyl chloride; indium(III) chloride / 1,2-dichloro-ethane / 21 h / Reflux

14: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

15: (1S)-10-camphorsulfonic acid / tetrahydrofuran / Reflux

With indium(III) chloride; lithium aluminium tetrahydride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; tributylphosphine; boron trifluoride diethyl etherate; (1S)-10-camphorsulfonic acid; diphenylsilyl chloride; tetrabutyl ammonium fluoride; sodium hydride; caesium carbonate; Dess-Martin periodane; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; 2-hydroxynitrobenzene; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 2: |Suzuki Coupling / 4: |Mitsunobu Displacement / 8: |Claisen Rearrangement;
DOI:10.1055/s-0032-1318114

Reference yield:

: C₁₈H₂₃NO₅

: 1422971-71-8
C₁₈H₂₁NO₄

Guidance literature:: Multi-step reaction with 8 steps

1: 2-hydroxynitrobenzene / 144 h / 130 °C / Inert atmosphere

2: sodium hydroxide / methanol; water / 80 °C

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

4: Dess-Martin periodane / dichloromethane

5: boron trifluoride diethyl etherate / dichloromethane / 3 h / -10 °C

6: diphenylsilyl chloride; indium(III) chloride / 1,2-dichloro-ethane / 21 h / Reflux

7: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

8: (1S)-10-camphorsulfonic acid / tetrahydrofuran / Reflux

With indium(III) chloride; boron trifluoride diethyl etherate; (1S)-10-camphorsulfonic acid; diphenylsilyl chloride; Dess-Martin periodane; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; 2-hydroxynitrobenzene; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane; 1: |Claisen Rearrangement;
DOI:10.1055/s-0032-1318114