6-(3-chloro-phenyl)-5-cyclopropyl-pyrazine-2-carboxylic acid (cyano-dimethyl-methyl)-amide

Base Information

Chemical Name:6-(3-chloro-phenyl)-5-cyclopropyl-pyrazine-2-carboxylic acid (cyano-dimethyl-methyl)-amide
CAS No.:1432506-06-3
Molecular Formula:C₁₈H₁₇ClN₄O
Molecular Weight:340.812
Hs Code.:

Synonyms:6-(3-chloro-phenyl)-5-cyclopropyl-pyrazine-2-carboxylic acid (cyano-dimethyl-methyl)-amide

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Chemical Property of 6-(3-chloro-phenyl)-5-cyclopropyl-pyrazine-2-carboxylic acid (cyano-dimethyl-methyl)-amide

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Technology Process of 6-(3-chloro-phenyl)-5-cyclopropyl-pyrazine-2-carboxylic acid (cyano-dimethyl-methyl)-amide

There total 6 articles about 6-(3-chloro-phenyl)-5-cyclopropyl-pyrazine-2-carboxylic acid (cyano-dimethyl-methyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: bromo(cyclopropyl)zinc

: 1432507-15-7
5-bromo-6-(3-chloro-phenyl)-pyrazine-2-carboxylic acid [1-methyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethyl]-amide

: 1432506-05-2
6-(3-chloro-phenyl)-5-cyclopropyl-pyrazine-2-carboxylic acid [1-methyl-1-(5-methyl-[1,2,4] oxadiazol-3-yl)-ethyl]-amide

: 1432506-06-3
6-(3-chloro-phenyl)-5-cyclopropyl-pyrazine-2-carboxylic acid (cyano-dimethyl-methyl)-amide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 0 - 20 ℃; Reflux;

Reference yield:

: 1432507-13-5
5-bromo-6-(3-chloro-phenyl)-pyrazine-2-carboxylic acid methyl ester

: 1432506-05-2
6-(3-chloro-phenyl)-5-cyclopropyl-pyrazine-2-carboxylic acid [1-methyl-1-(5-methyl-[1,2,4] oxadiazol-3-yl)-ethyl]-amide

: 1432506-06-3
6-(3-chloro-phenyl)-5-cyclopropyl-pyrazine-2-carboxylic acid (cyano-dimethyl-methyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 1.5 h / 20 °C

2.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 20 °C

2.2: 0.5 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 0 °C / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; water; lithium hydroxide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1432507-12-4
5-amino-6-(3-chloro-phenyl)-pyrazine-2-carboxylic acid methyl ester

: 1432506-05-2
6-(3-chloro-phenyl)-5-cyclopropyl-pyrazine-2-carboxylic acid [1-methyl-1-(5-methyl-[1,2,4] oxadiazol-3-yl)-ethyl]-amide

: 1432506-06-3
6-(3-chloro-phenyl)-5-cyclopropyl-pyrazine-2-carboxylic acid (cyano-dimethyl-methyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: isopentyl nitrite / dichloromethane / 0.25 h / 20 °C

1.2: 1 h / 20 °C

2.1: water; lithium hydroxide / tetrahydrofuran / 1.5 h / 20 °C

3.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 20 °C

3.2: 0.5 h / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 0 °C / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; water; lithium hydroxide; isopentyl nitrite; In tetrahydrofuran; dichloromethane;