(3aR,7aR)-1-(4'-bromobenzyl)-2-(2''-(diphenylphosphanyl)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole

Base Information

Chemical Name:(3aR,7aR)-1-(4'-bromobenzyl)-2-(2''-(diphenylphosphanyl)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole
CAS No.:1301708-38-2
Molecular Formula:C₃₂H₃₀BrN₂P
Molecular Weight:553.481
Hs Code.:

Synonyms:(3aR,7aR)-1-(4'-bromobenzyl)-2-(2''-(diphenylphosphanyl)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole

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Chemical Property of (3aR,7aR)-1-(4'-bromobenzyl)-2-(2''-(diphenylphosphanyl)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole

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Technology Process of (3aR,7aR)-1-(4'-bromobenzyl)-2-(2''-(diphenylphosphanyl)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole

There total 5 articles about (3aR,7aR)-1-(4'-bromobenzyl)-2-(2''-(diphenylphosphanyl)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: (3aR,7aR)-2-(2'-(diphenylphosphanyl)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole

: 589-15-1
1-bromomethyl-4-bromobenzene

: 1301708-38-2
(3aR,7aR)-1-(4'-bromobenzyl)-2-(2''-(diphenylphosphanyl)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole

Guidance literature:: (3aR,7aR)-2-(2'-(diphenylphosphanyl)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole; With potassium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;

1-bromomethyl-4-bromobenzene; With tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; at 20 ℃; for 19h; Inert atmosphere;
DOI:10.1002/chem.201003314

Reference yield:

: 503111-21-5
(3aR,7aR)-2-(2'-fluorophenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole

: 1301708-38-2
(3aR,7aR)-1-(4'-bromobenzyl)-2-(2''-(diphenylphosphanyl)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: potassium hydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2.2: 19 h / 20 °C / Inert atmosphere

With potassium hydride; In tetrahydrofuran;
DOI:10.1002/chem.201003314

Reference yield:

: 445-28-3
2-fluorobenzamide

: 1301708-38-2
(3aR,7aR)-1-(4'-bromobenzyl)-2-(2''-(diphenylphosphanyl)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 19.3 h / 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 64 h / 20 °C / Inert atmosphere

3.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4.1: potassium hydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

4.2: 19 h / 20 °C / Inert atmosphere

With potassium hydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/chem.201003314